Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
Recruiting · NCT07245121 · Interventional (participants receive a specific treatment) · Lead sponsor: National and Kapodistrian University of Athens
View the official record on ClinicalTrials.gov →Interventions studied
Dextrose 5% and LidocaineLidocaine
What this trial is about
The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated. To enhance the potential therapeutic effect, we will proceed to a 4-point injection technique, targeting 4 genicular nerves (superomedial, superolateral, inferomedial, recurrent peroneal genicular nerve) in a randomized controlled trial with two arms.
Who can take part
Age range
38 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients of both sexes
- Age \>38 years
- Body Mass Index (BMI) up to 42 kg/m2
- Diagnosis of knee osteoarthritis, according to the clinical criteria of the American College of Rheumatology. Osteoarthritis if the following combinations are present:
- A, B, C, D or A, B, E or A, D, E:
- A) Knee pain most days of the previous month B) Cracking during active joint movement C) Morning stiffness lasting at least 30 minutes D) Age at least 38 years E) Bone swelling of the affected knee on physical examination
- Chronic knee pain on the Numerical Rating Scale (NRS) \> 5 for at least 3 months prior to the study
- Grade 2 or 3 osteoarthritis, according to the Kellgern-Lawrence classification
- Pain, creaking, and stiffness in the knee joint that persists for at least three months prior to the study.
Exclusion criteria
- Any infection of the skin of the knee joint, such as cellulitis, or periarticular or intraarticular infection during the last 3 months
- Poorly controlled diabetes mellitus or connective tissue disease affecting the knee joint
- History of previous total knee arthroplasty or other knee surgery.
- History of periarticular or intraarticular injection of corticosteroids, local anesthetic, hyaluronic acid, platelet-rich plasma, radiofrequency, prolotherapy within the last trimester
- History of knee injury or fracture within the last 3 months
- History of acute lumbosacral radiculopathy or peripheral neuropathy, neurological, psychiatric disease
- Pain limited in the posterior aspect of the knee
- History of limb malignancy
- History of bleeding disorder
- Pregnancy
- Allergy to local anesthetics, needle phobia
- Difficulty communicating (severe hearing loss, dementia, language problems)
- Non-guaranteed transportation to hospital for treatments and re-evaluations
Where it is running
1 location listed.
- University General Hospital of Athens "Attikon" - National and Kapodistrian University of Athens Medical School - Athens, Attica, Greece