Thyroid-Stimulating Hormone Levels in Pregnancy and Their Association With Depression, Anxiety, and Sexual Function
Recruiting · NCT07272213 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →What this trial is about
This prospective, single-center, observational cross-sectional study aims to evaluate the relationship between thyroid-stimulating hormone (TSH) levels and psychological as well as sexual health outcomes during pregnancy. Pregnant individuals will undergo psychometric assessment using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), the Arizona Sexual Experience Scale (ASEX), and the YKK-13 Quality of Life Scale. The study will investigate whether maternal TSH levels are associated with depression, anxiety, sexual function, and overall quality of life scores. Eligible participants will be pregnant women aged 18-45 years with a singleton pregnancy of at least 6 weeks, who are literate and have provided informed consent. Individuals with a prior psychiatric history, multiple gestation, or existing systemic or endocrine diseases will be excluded. The primary endpoint of the study is to determine the association between TSH levels and psychometric scale scores during pregnancy.
Who can take part
Inclusion criteria
- Pregnant women aged 18-45 years
- Singleton pregnancy
- Gestational age ≥ 6 weeks
- Literacy and ability to provide informed consent
- Availability of a TSH result obtained within the past 4 weeks
- Cognitive ability sufficient to complete the psychometric questionnaires (Beck Depression Inventory, Beck Anxiety Inventory, ASEX, and YKK-13 Quality of Life Scale)
Exclusion criteria
- Multiple pregnancy
- Previously diagnosed psychiatric disorder or active use of antidepressant/ anxiolytic medication
- Current treatment for thyroid disease
- History of thyroid surgery
- Major systemic illness or significant obstetric complications
- Age under 18 years or inability to provide informed consent
- Inability to complete the questionnaires adequately (missing or invalid data)
- Rationale:
- Multiple pregnancies are excluded because they differ significantly from singleton pregnancies in terms of hormonal profile, obstetric risks, and psychological stress levels. This exclusion aims to ensure a homogeneous study population.
Where it is running
1 location listed.
- SBÜ Gaziosmanpaşa Training and Research Hospital - Istanbul, Gaziosmanpaşa, Turkey (Türkiye)