Neurobiological and Genomic Predictors of Relapse in Depression
Recruiting · NCT07328373 · Observational (researchers observe without assigning treatment) · Lead sponsor: Mehmet Kemal Arikan
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters. The main questions it aims are: 1. When patients with depression treated with antidepressants, does their brain activity also become normal? If so, 2. Then, can we stop the antidepressant treatment and expect minimum repeat of depression? The participants who receive a specific antidepressant treatment will be asked to: * Undergo quantitative electroencephalography (qEEG), * Record Event-related potential (ERP), * Record Sleep EEG * Answer Hamilton Depression Rating Scale question their psychiatrists asked * Give blood sample for genetic analysis * Repeat the above mentioned procedures for at least 3 times during their treatment period. Researchers will compare the results of patients with the results of healthy controls.
Who can take part
Inclusion criteria
- Outpatients
- For patients, satisfying Major Depressive Disorder for Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR)
- Drug-free for at least 1-week
Exclusion criteria
- Any neurological and psychiatric comorbid conditions
- Hearing loss
- Physical diseases
Where it is running
1 location listed.
- Prof. Dr. Kemal Arıkan's Psychiatry Clinic - Istanbul, Turkey (Türkiye)