" TREX1 Gene Mutations and Their Role in Systemic Lupus Erythematosus
Recruiting · NCT07397728 · Observational (researchers observe without assigning treatment) · Lead sponsor: South Valley University
View the official record on ClinicalTrials.gov →Interventions studied
TREX1 gene polymorphisms
What this trial is about
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by diverse clinical manifestations, prominently involving the skin.
Who can take part
Age range
18 Years to 60 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Adult aged 18-60 years
- Diagnosed as SLE per 2019 EULAR/ACR classification criteria.
- Presence of at least one cutaneous manifestation (acute, subacute, or chronic).
- Willing to provide written informed consent for participation and genetic testing
Exclusion criteria
- Overlap autoimmune syndromes (e.g., dermatomyositis, systemic sclerosis).
- Systemic infection, malignancy, or pregnancy.
- Use of biologic therapy or immunosuppressive pulses within one month.
Where it is running
1 location listed.
- Qina University hospital, South Valley University Hospital - Qina, South Valley, Egypt