Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Recruiting · NCT07425457 · Interventional (participants receive a specific treatment) · Lead sponsor: Attikon Hospital
View the official record on ClinicalTrials.gov →Interventions studied
CT-guided Cryoneurolysis of the Genicular Nerves
What this trial is about
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Adults ≥18 years undergoing primary TKA for osteoarthritis.
- Cognitively normal and able to self-assess pain and function.
- Provide written informed consent.
Exclusion criteria
- Cancer-related knee pain.
- Neurological, psychiatric, or medical conditions interfering with assessment.
- Chronic opioid users.
Where it is running
1 location listed.
- Attikon University General Hospital - Athens, Greece