The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms
Recruiting · NCT07469462 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Reading
View the official record on ClinicalTrials.gov →Interventions studied
Placebo SupplementationPyridoxal-5'-Phosphate supplement
What this trial is about
This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.
Who can take part
Age range
18 Years to 41 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Over 18 years of age and under 41
- Mild to moderate anxiety and/or depression
- Normal or corrected to normal vision
Exclusion criteria
- not taking daily dietary supplement containing \>2 mg Vitamin B6
- not taking medication that is a GABA agaonist (our team will check this with you)
- not be pregnant
- no medical history of epilepsy
- no medical history of peripheral neuropathy
- not taking the antibiotic Seromycin (prescribed for tuberclosis or urinary tract infection)
- no history of brain injury or recent concussion
Where it is running
1 location listed.
- Harry Pitt Building - Reading, England, United Kingdom