Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine
Recruiting · NCT07500714 · Interventional (participants receive a specific treatment) · Lead sponsor: National Science and Technology Council, Taiwan
View the official record on ClinicalTrials.gov →Interventions studied
Internet Cognitive-Behavioral TherapySham treatment
What this trial is about
This project aims to integrate digital phenotyping and AI-driven iCBT into a comprehensive platform for MDD diagnosis and treatment in Taiwan. The study will explore dynamic, real-time behavioral and physiological markers to refine diagnostic classifications and optimize personalized therapeutic strategies.
Who can take part
Age range
18 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- (1) Aged 18-75 years
- Diagnosis of major depressive disorder disorder (Based on Diagnostic Statistical Manual 5)
- 21-item Hamilton Depression Scale (HAMD21)\>17
- No changes in current psychiatric treatment for depression (e.g., no treatment, antidepressant medication, psychotherapy, or non-invasive brain stimulation) within the past four weeks, and
- Full competency to understand the study details and provide written informed consent
Exclusion criteria
- Scores of 5 ( Markedly ill), 6,(Severely ill), and 7 (Among the most extremely ill) according to the Clinical Global Impression Scale-Severity (CGI-S)
- Psychotic disorders, bipolar affective disorder, a substance use disorders in the past 6 months, active suicidal or homicidal ideation (per assessment or HAMD\>3)
- Unstable or active medical illness.
Where it is running
1 location listed.
- Mind Body Interface Research Center (MBI Lab & Care) - Taichung, Taichung, Taiwan