Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis

Recruiting · NCT07666347 · Interventional (participants receive a specific treatment) · Lead sponsor: Tanta University

Interventions studied

Botulinum toxin type AHyaluronic acid

This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.

Age range

50 Years and older

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Age ≥ 50 years.
Both genders.
Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis.
Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites and projections.

History of intra-articular injection within the last 6 months,
History of surgery on the knee joint or major trauma to the lower limb causing fracture.
Body mass index (BMI) more than 40 kg/m2.
Medical conditions affecting the joint or lower extremity function such as severe osteoporosis, rheumatoid arthritis, collagen vascular diseases, and gout.
Diabetic patient.
Any contraindication to intra-articular injections for instance immunodeficiency, coagulation defect or anticoagulation therapy taking or skin infection at the site of injection.
Hypersensitivity to Botulinum toxin or hyaluronic acid.

1 location listed.