Preoperative Genicular Radiofrequency and Functional Outcomes After Total Knee Arthroplasty
Recruiting · NCT07727551 · Interventional (participants receive a specific treatment) · Lead sponsor: Anesthesiology department Iris South Hospitals
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Knee osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage wear, leading to pain, stiffness, and joint swelling. It is highly prevalent in aging populations and is strongly associated with obesity and previous joint injury. OA affects millions of individuals worldwide, with incidence and prevalence increasing markedly with age and resulting in significant functional disability The primary therapeutic goals in the management of knee osteoarthritis are pain reduction and improvement of joint mobility. Total knee arthroplasty is considered one of the most effective surgical interventions for relieving pain and restoring function in patients with severe knee osteoarthritis. Nevertheless, residual pain and limited functional improvement remain the most frequent causes of patient dissatisfaction following TKA Genicular nerve radiofrequency ablation (GNRFA) has emerged as an innovative treatment option for symptomatic knee osteoarthritis. This technique has been shown to reduce pain and improve function, with clinical benefits often observed as early as one week after treatment. GNRFA consistently provides short-term pain relief (3 to 6 months) and, in some cases, longer-lasting benefits. The hypothesis tested in this study is whether GNRFA performed at least two weeks preoperatively can reduce postoperative pain and improve postoperative function.
Who can take part
Inclusion criteria
- Age between 18 and 60
- Elective total knee arthroplasty
- 2 to 6 weeks before the procedure
- AND either of:
- BMI \> 35
- Diabetes under insulin
- Anxiety disorder
- Treated depressive disorder
- Widespread pain disorder or central sensitisation disorder
- Chronic pain at a different site
- Catastrophising
- Sleep disorder
- preoperative EVA 7 or more
- OKS 25 or less
- WOMAC 50 or more
- Previous total knee arthroplasty (contralateral)
- Knee CRPS
Exclusion criteria
- Previous prosthetic surgery on the same knee (i.e. redo surgery, open reduction internal fixation, knee hemiarthroplasty)
- Major psychiatric disorder (i.e. major depression, schizophrenia)
- Patient refusal
- Inability to communicate with the patient and obtain informed consent
Where it is running
1 location listed.
- Iris South Hospitals - Brussels, Belgium