Eccentric vs Low-Load Blood Flow Restriction Training in Knee Osteoarthritis in Knee Osteoarthritis
Recruiting · NCT07733518 · Interventional (participants receive a specific treatment) · Lead sponsor: Riphah International University
View the official record on ClinicalTrials.gov →Interventions studied
Eccentric Gastrocnemius Strengthening ExercisesLow-Load Blood Flow Restriction Training
What this trial is about
The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with knee osteoarthritis
Who can take part
Age range
40 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age group 40-70
- Both genders male and female
- Clinical diagnosis of knee OA (Kellgren-Lawrence grade 1-3) of the most symptomatic knee.
- Pain stable enough to permit exercise on Numeric Pain Rating Scale 3/10.
- Participants must demonstrate a gastrocnemius muscle strength of grade ≥3 on the Manual Muscle Testing (MMT) scale (0-5), assessed using the standard standing heel-rise position.
- Participants must be able to ambulate independently and participate in supervised exercise.
Exclusion criteria
- • Presence of a prosthetic knee in the affected limb.
- Inflammatory arthritis (e.g., rheumatoid arthritis) or active flare-up of OA.
- Cardiovascular disease contraindicating exercise (e.g., unstable angina, recent MI, uncontrolled hypertension ≥160/100 mmHg).
- Pulmonary disease that limits safe participation (e.g., severe COPD, recent exacerbation).
- History of deep vein thrombosis (DVT), peripheral vascular disease, or bleeding/clotting disorders.
- Current anticoagulant therapy that increases bleeding risk (unless cleared by physician).
- Any pathology causing significant muscle weakness (e.g., neuromuscular disorders, severe neuropathy).
Where it is running
1 location listed.
- Railway General Hospital, Rawalpindi - Rawalpindi, Punjab Province, Pakistan