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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
NCT07033494 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Newton
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A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07170150 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Watertown
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A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
NCT07094516 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Methuen
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A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
NCT06297590 ·
Phase: Phase 1 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Charlestown
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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
NCT07011745 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Worcester
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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
NCT07011732 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Foxborough, Newton, South Dartmouth, Springfield
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A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
NCT07602582 ·
Phase: Phase 3 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Massachusetts: Newton, Waltham
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A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
NCT07589595 ·
Phase: Phase 2 ·
Ages: 55 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Charlestown, Foxborough, Plymouth
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A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07169578 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Newton
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A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
NCT05462106 ·
Phase: Phase 1, Phase 2 ·
Ages: 35 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
NCT06651567 ·
Phase: Phase 2 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
NCT07599670 ·
Phase: Phase 1, Phase 2 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Watertown
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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
NCT06585787 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston, North Dartmouth, South Dartmouth
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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
NCT06976216 ·
Phase: Phase 3 ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Newton
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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
NCT06976203 ·
Phase: Phase 3 ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Watertown
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A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06937229 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Newton, Worcester
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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
NCT06563895 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Assess Fibrin in Brains With AD/ADRD
NCT05336695 ·
Phase: Phase 1, Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
NCT06489548 ·
Phase: Phase 2 ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
NCT07236190 ·
Phase: Phase 2 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)
NCT07496918 ·
Phase: Phase 2 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Cambridge
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Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy
NCT05655195 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Cambridge
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Cognitive Neurology Unit Clinical Registry
NCT05925621 ·
Phase: Not specified ·
Ages: 50 Years to 95 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
NCT04124029 ·
Phase: Not specified ·
Ages: 30 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type
NCT06052254 ·
Phase: Phase 2 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Massachusetts: Springfield, Worcester
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Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
NCT05881239 ·
Phase: Not specified ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Dominantly Inherited Alzheimer Network (DIAN)
NCT00869817 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Gamma Frequency Stimulation in Individuals With Down Syndrome
NCT05196984 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 25 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Cambridge
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Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease
NCT05776641 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Cambridge
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Gamma-Music Based Intervention for Mild Alzheimer's Disease
NCT05984524 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 95 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
NCT06821568 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Roslindale
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Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
NCT06094192 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
NCT05904132 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 80 Years ·
Sex: All (male and female)
· Massachusetts: Charlestown
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Making Connections Thru Music
NCT06079216 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 103 Years ·
Sex: All (male and female)
· Massachusetts: Winchester
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Mindfulness for Cognition in Early-stage Alzheimer's Disease
NCT06792877 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 100 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
NCT05661084 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
NCT05980949 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston, North Dartmouth, Springfield
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PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
NCT02649985 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
NCT05245903 ·
Phase: Not specified ·
Ages: 18 Years to 89 Years ·
Sex: All (male and female)
· Massachusetts: Belmont
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Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
NCT07177352 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Newton, Watertown
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Sleep-dependent Learning in Aging
NCT03840083 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Massachusetts: Amherst
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Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
NCT06847321 ·
Phase: Phase 2 ·
Ages: 55 Years to 80 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Plymouth, Watertown
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Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
NCT06808984 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Foxborough, South Dartmouth
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TMS for Cognitive Decline in Aging and Preclinical AD
NCT06956300 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years to 99 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
NCT05658913 ·
Phase: Not specified ·
Ages: 18 Years to 120 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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The BRAIN App (Phase 2 SBIR)
NCT06298474 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years and older ·
Sex: All (male and female)
· Massachusetts: Winchester
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Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
NCT06538311 ·
Phase: Early Phase 1 ·
Ages: 40 Years to 99 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Triage Survey for Neurology Research Eligibility
NCT06104852 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston, Watertown
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Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
NCT05950607 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 60 Years to 106 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Trial-Ready Cohort-Down Syndrome (TRC-DS)
NCT04165109 ·
Phase: Not specified ·
Ages: 25 Years to 55 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease
NCT07659964 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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[18F]PI-2620 Phase 3 Histopathological Study
NCT05641688 ·
Phase: Phase 3 ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Massachusetts: Braintree, Plymouth