Clinical trials recruiting for Chronic Migraine

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
  NCT07018713 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 111 locations
• A Study Investigating Peripheral Cryoneurolysis in Adults With Chronic Migraine
  NCT06554886 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
  NCT06810505 · Phase: Phase 3 · Ages: 12 Years to 17 Years · Sex: All (male and female) · 64 locations
• A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults
  NCT06625060 · Phase: Phase 2 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 166 locations
• Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine
  NCT06795867 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
  NCT03231241 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
  NCT05754190 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• BOTOX® vs. XEOMIN® for Chronic Migraine
  NCT05598723 · Phase: Phase 3 · Ages: 18 Years to 89 Years · Sex: All (male and female) · 1 location
• Biochemical Profiling of Migraine Patients
  NCT06549270 · Phase: Not specified · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• CGRP Inhibition, Autonomic Function, and Migraine
  NCT04628429 · Phase: Not specified · Ages: 18 Years to 64 Years · Sex: All (male and female) · 3 locations
• Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial
  NCT05337033 · Phase: Phase 2 · Ages: 14 Years to 17 Years · Sex: All (male and female) · 3 locations
• Cannabis for the Prophylactic Treatment of Migraine
  NCT03972124 · Phase: Phase 2 · Ages: 25 Years and older · Sex: All (male and female) · 1 location
• Determining the Utility of a Behavioral Intervention in Chronic Migraine
  NCT05415020 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Effect of Nebulized Dexmedetomidine on Central Sensitization and Chronification in Migraine
  NCT07769255 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients
  NCT06309251 · Phase: Not specified · Ages: Up to 18 Years · Sex: All (male and female) · 6 locations
• Efficacy of Nerve Block Versus Botox in Chronic Migraine Management
  NCT06684249 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Gepant treAtments: EffectIveNess and tolERability (GAINER)
  NCT05903027 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)
  NCT05769348 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Laser Acupuncture for Chronic Migraine
  NCT06219694 · Phase: Not applicable (e.g. observational or device study) · Ages: 20 Years and older · Sex: All (male and female) · 1 location
• Mind Body Balance for Pediatric Migraine
  NCT04715685 · Phase: Not applicable (e.g. observational or device study) · Ages: 10 Years to 17 Years · Sex: All (male and female) · 2 locations
• Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine
  NCT06603558 · Phase: Not specified · Ages: 19 Years and older · Sex: All (male and female) · 36 locations
• Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)
  NCT06485336 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 6 locations
• Responding With Evidence and Access for Childhood Headaches
  NCT05889624 · Phase: Not applicable (e.g. observational or device study) · Ages: 10 Years to 17 Years · Sex: All (male and female) · 15 locations
• Searching for Novel Biological Phenotypes in Migraine Patients Resistant to Treatments
  NCT06562413 · Phase: Not specified · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments
  NCT06562400 · Phase: Not specified · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine
  NCT06974617 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy
  NCT03404336 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• The RECLAIM Study.
  NCT06450444 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 84 Years · Sex: All (male and female) · 11 locations
• Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult
  NCT06322407 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• i-NEED: NEw migrainE Drugs Database
  NCT07103694 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations

Related conditions

Trials recruiting for Chronic Migraine often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Chronic Migraine trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.