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A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
NCT06428409 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
NCT06750094 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
NCT06662786 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
NCT07213791 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
NCT05877599 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
NCT03093116 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Wisconsin: Appleton
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A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
NCT05592626 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)
NCT07416552 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
NCT06885034 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
NCT03175224 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.
NCT07033026 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Appleton
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Wisconsin: Antigo, Appleton, Ashland, Baraboo
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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
NCT05174169 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Antigo, Appleton, Ashland, Berlin
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Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial
NCT07227077 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain
NCT06848348 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
NCT07018869 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Appleton, Ashland, Green Bay, Hayward
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FOG-001 in Locally Advanced or Metastatic Solid Tumors
NCT05919264 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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Family Communications After Genetic Testing
NCT07143487 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Ashland, Hayward, New Richmond, Spooner
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Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
NCT05080673 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years to 70 Years ·
Sex: All (male and female)
· Wisconsin: Appleton, Ashland, Brookfield, Chilton
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Integrated Cancer Repository for Cancer Research
NCT02012699 ·
Phase: Not specified ·
Ages: 19 Years to 110 Years ·
Sex: All (male and female)
· Wisconsin: Green Bay
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KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
NCT06026410 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
NCT06073431 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Appleton, Brookfield, Burlington, Chilton
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Lead-212 PSV359 Therapy for Patients With Solid Tumors
NCT06710756 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Wisconsin: Madison
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MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06586515 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
NCT06050707 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer
NCT04808323 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
NCT03998202 ·
Phase: Not specified ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Wisconsin: Ashland, Eau Claire, Green Bay, Marshfield
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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
NCT06205485 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Eau Claire, Marshfield, Minocqua, Rice Lake
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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Appleton
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Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
NCT06625775 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
NCT06218914 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
NCT07228832 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
NCT07351071 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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Self-sampling to Optimize Anal Lesion Outcomes
NCT07192055 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 35 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers
NCT05239546 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT05489211 ·
Phase: Phase 2 ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· Wisconsin: Madison
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Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
NCT06493019 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
NCT05855200 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Appleton
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Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
NCT05176483 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Milwaukee
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Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
NCT07283939 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Antigo, Appleton, Ashland, Brookfield
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Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
NCT05234177 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Appleton
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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
NCT05863195 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison
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Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study
NCT05673148 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Wisconsin: Antigo, Appleton, Brookfield, Chilton
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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
NCT04585750 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Wisconsin: Madison