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A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
NCT07592689 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· Missouri: St Louis
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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NCT03887715 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia, O'Fallon, St Louis
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A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
NCT07172516 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· Missouri: O'Fallon
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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
NCT06775379 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· Missouri: St Louis
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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
NCT07076407 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· Missouri: O'Fallon, Saint Charles
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A Study of Brenipatide in Adult Participants With Major Depressive Disorder
NCT07412756 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Missouri: St Louis
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A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
NCT06696755 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: Saint Charles
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A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
NCT06524830 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: Saint Charles
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A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
NCT07065240 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: St Louis
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A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
NCT06223880 ·
Phase: Phase 4 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: Saint Charles
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A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT07196501 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: O'Fallon
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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
NCT07284667 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: Saint Charles
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Adolescent Chatbot
NCT07094503 ·
Phase: Phase 2 ·
Ages: 13 Years to 19 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Brain Stimulation for Severe Depression
NCT05393622 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years to 80 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Clinical Trial on Agitation in Alzheimer's Dementia
NCT05543681 ·
Phase: Phase 2 ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Depression and Driving
NCT05446805 ·
Phase: Not specified ·
Ages: 65 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
NCT06636058 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 74 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
NCT05905705 ·
Phase: Not specified ·
Ages: 21 Years to 65 Years ·
Sex: All (male and female)
· Missouri: St Louis
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E-Mindfulness Approaches for Living After Breast Cancer
NCT06748222 ·
Phase: Phase 3 ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· Missouri: Osage Beach, Saint Joseph, Springfield, St Louis
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Efficacy of a Multi-level School Intervention for LGBTQ Youth
NCT05541406 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 12 Years to 20 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
NCT06830044 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: Saint Charles
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Fresh RX: NHS 2020
NCT04845230 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 14 Years to 55 Years ·
Sex: Female
· Missouri: St Louis
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INCLUDE Program: A Perioperative Wellness Program Tailored for Black Surgical Patients
NCT07283783 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
NCT06978166 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City
NCT07673380 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06966401 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: O'Fallon, Saint Charles
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Lumateperone for Late-Life Depression
NCT07623135 ·
Phase: Phase 3 ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
NCT06372964 ·
Phase: Phase 3 ·
Ages: 10 Years to 17 Years ·
Sex: All (male and female)
· Missouri: Saint Charles, St Louis
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Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
NCT07494305 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: St Louis
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NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06911112 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Saint Charles
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NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
NCT02994433 ·
Phase: Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation
NCT07607730 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years to 17 Years ·
Sex: All (male and female)
· Missouri: Kansas City
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Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
NCT06867549 ·
Phase: Phase 2 ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
NCT06633016 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: Saint Charles
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Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
NCT05850689 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Missouri: O'Fallon
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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NCT06423430 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years to 70 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
NCT06162741 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis