Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Recruiting · NCT05905705 · Observational (researchers observe without assigning treatment) · Lead sponsor: Washington University School of Medicine
View the official record on ClinicalTrials.gov →Interventions studied
Electroencephalography (EEG)Quantitative Measurements of Sleep Microstructure
What this trial is about
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.
Who can take part
Age range
21 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.
Exclusion criteria
- Diagnoses of schizophrenia or schizoaffective disorders.
- Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.
Where it is running
1 location listed across 1 US state.
- Washington University School of Medicine/Barnes-Jewish Hospital - St Louis, Missouri, United States