Clinical trials recruiting for Depressive Symptoms

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

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Recruiting trials

• A New Clinical Model for the Engagement of Latinx Youth With Suicidal Behavior
  NCT06882798 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 18 Years · Sex: All (male and female) · 1 location
• A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV
  NCT06586619 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 75 Years · Sex: All (male and female) · 1 location
• Activating Social Resources in Psychotherapy-Seeking Individuals: Effectiveness and Timing of a Social Support Just-in-Time Adaptive Intervention
  NCT07471529 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
  NCT04245436 · Phase: Phase 4 · Ages: 12 Years to 17 Years · Sex: All (male and female) · 2 locations
• Assessment of Daily Stressors in Children With Depressive Symptoms for the Development of a Gamified Emotion Regulation App
  NCT07159347 · Phase: Not specified · Ages: 8 Years to 12 Years · Sex: All (male and female) · 1 location
• Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia
  NCT04084795 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: Female · 1 location
• BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women
  NCT07413705 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: Female · 3 locations
• BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Urinary Incontinence in Postpartum and Early Post-Childbirth Women
  NCT07413692 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 60 Years · Sex: Female · 3 locations
• Behavioral Activation for the Prevention and Treatment of Depression in Older Adults in a Municipal Context
  NCT06415838 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Cancer Pain Management Using a Web-based Intervention
  NCT06085313 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: Female · 1 location
• Cannabidiol for Reduction of Brain Neuroinflammation
  NCT05066308 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants
  NCT06828276 · Phase: Not applicable (e.g. observational or device study) · Ages: 15 Years to 29 Years · Sex: All (male and female) · 1 location
• Depression and Suicide Prevention in Adolescents Attending Special Schools
  NCT06203899 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 18 Years · Sex: All (male and female) · 1 location
• Depressive Symptoms After Cardiac Surgery
  NCT06706323 · Phase: Not specified · Ages: 18 Years to 90 Years · Sex: All (male and female) · 4 locations
• Dog Presence and Oxytocin on Trust Towards Therapists
  NCT06248710 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Effectiveness of a Guided Mobile App Intervention for Depression and Anxiety in University Students (PROMES-U Study)
  NCT06078007 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Efficacy and Safety of Auricular Acupuncture in Depression During the Covid 19 Pandemic
  NCT05855421 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 50 Years · Sex: All (male and female) · 1 location
• Expressive Writing on Minority Stressors Among Sexual Minority Veterans
  NCT05897021 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Family Spirit Strengths
  NCT05836090 · Phase: Not applicable (e.g. observational or device study) · Ages: 14 Years and older · Sex: Female · 6 locations
• Feasibility and Effects of a Blended Baduanjin Exercise and Green Tea Consumption Program on Depressive Symptoms, Gut Microbiota and Quality of Life in Older Adults
  NCT07687940 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 84 Years · Sex: All (male and female) · 1 location
• IMB-Based Sleep Hygiene Education for Menopausal Women: Effects on Sleep Quality and Depression
  NCT07299903 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 60 Years · Sex: Female · 1 location
• IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
  NCT06582784 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Implementation of Bright Light Therapy ID
  NCT06215235 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)
  NCT07020572 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 17 Years · Sex: All (male and female) · 1 location
• Improving Sleep to Prevent Depression & Anxiety in Adolescents at High Risk
  NCT06358495 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 18 Years · Sex: All (male and female) · 1 location
• Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice
  NCT07009223 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 80 Years · Sex: All (male and female) · 1 location
• Low Voltage Electrical Stimulation for Depression in Parkinson's Patients
  NCT06467695 · Phase: Not applicable (e.g. observational or device study) · Ages: 19 Years to 65 Years · Sex: All (male and female) · 1 location
• Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
  NCT07654179 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 4 locations
• Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
  NCT06574035 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: Male · 1 location
• Mind-Body Skills Group for Graduate Students
  NCT05447689 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Mindfulness Engaged Neurostimulation for Depression (MEND II)
  NCT07512284 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Mobile CBT for Middle Aged and Older Adults
  NCT05754151 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• Morning Activation to Improve Mood After Stroke
  NCT07719517 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Music Therapy's Impact on University Students' Social and Mental Health
  NCT07024979 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 35 Years · Sex: Female · 1 location
• My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
  NCT05369429 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Natural History of Depression, Bipolar Disorder and Suicide Risk
  NCT06462196 · Phase: Not specified · Ages: 18 Years to 120 Years · Sex: All (male and female) · 1 location
• Non-pharmacological Care for Depression in Cancer Patients Using VR and TMS
  NCT06589544 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 100 Years · Sex: All (male and female) · 2 locations
• Online or In-person Interventions on Anxiety and Depression Symptoms in Caregivers of Patients with Cancer
  NCT06592573 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Our Voices Matter: Intervention for Depression in Youth
  NCT07216326 · Phase: Not applicable (e.g. observational or device study) · Ages: 15 Years to 20 Years · Sex: All (male and female) · 1 location
• Profiling the Dynamic of Binge Eating Disorder (PRODY-BED)
  NCT05726721 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
  NCT04123314 · Phase: Early Phase 1 · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Psychological Well-Being, Depression, and Health-Related Quality of Life in Adults With Type 2 Diabetes: A Cross-Sectional Study
  NCT07241325 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
  NCT03794531 · Phase: Not specified · Ages: 30 Years to 75 Years · Sex: All (male and female) · 1 location
• RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
  NCT05658796 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 100 Years · Sex: All (male and female) · 3 locations
• Sleep More, Stress Less: 90-Day Trial of Neuralli Mood
  NCT07717385 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Social Worker-led Mindfulness-based Intervention for Older People
  NCT06528132 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 13 locations
• Stepping Together for Children After Trauma, Norway
  NCT05734547 · Phase: Not applicable (e.g. observational or device study) · Ages: 7 Years to 12 Years · Sex: All (male and female) · 2 locations
• Strength and Pain-Coping Through Resilience and Knowledge
  NCT07228520 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Strengthening Health and Insight in New Educators
  NCT06745934 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients
  NCT07639359 · Phase: Phase 2 · Ages: 18 Years to 99 Years · Sex: All (male and female) · 2 locations
• Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)
  NCT05752448 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: Female · 3 locations
• Telephone-coached "Graphic Narrative" Bibliotherapy for Dementia Caregivers
  NCT06413849 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Testing the Effectiveness of Supportive Parents - Coping Kids
  NCT05800522 · Phase: Not applicable (e.g. observational or device study) · Ages: 4 Years to 12 Years · Sex: All (male and female) · 2 locations
• The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study
  NCT06206226 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The Supplementation Therapy in Autism and Response to Treatment Study
  NCT06187090 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 35 Years · Sex: All (male and female) · 1 location
• Trauma-Focused Cognitive Behavioral Therapy in Unaccompanied Refugee Minors With PTSD in Greece: An RCT
  NCT06975280 · Phase: Not applicable (e.g. observational or device study) · Ages: 15 Years to 18 Years · Sex: All (male and female) · 1 location
• Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
  NCT05567640 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• VR-PMR for Post-Burn Symptoms
  NCT07317271 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE)
  NCT07055906 · Phase: Not applicable (e.g. observational or device study) · Ages: 10 Years to 14 Years · Sex: All (male and female) · 1 location
• rTMS Combined With Aerobic Exercise for Older Adults With Mild Cognitive Impairment and Comorbid Depression
  NCT07652775 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 90 Years · Sex: All (male and female) · 1 location
• rTMS for Military TBI-related Depression
  NCT05426967 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 3 locations

Related conditions

Trials recruiting for Depressive Symptoms often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Depressive Symptoms trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.