Clinical trials recruiting for Depressive Disorder

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• 7T Amygdala and Citalopram Study
  NCT06412315 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 40 Years · Sex: All (male and female) · 1 location
• A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
  NCT06508450 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 34 Years · Sex: All (male and female) · 1 location
• A Randomized Neuroimaging Trial of Psilocybin in Depression
  NCT06072898 · Phase: Phase 2 · Ages: 18 Years to 64 Years · Sex: All (male and female) · 1 location
• Acute Efficacy and 6 Months Follow up After Electroconvulsive Therapy
  NCT05388461 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Adaptation of Individual Dialectical Behavior Therapy Intervention for Transdiagnostic Treatment of Emotional Disorders
  NCT05989451 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Aerobic Exercise as an Adjunct Therapy for Depression
  NCT07819448 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• An Innovative Master Platform for Clinical Trials in Mood Disorders
  NCT06408012 · Phase: Not specified · Ages: 16 Years and older · Sex: All (male and female) · 9 locations
• Assessment of Daily Stressors in Children With Depressive Symptoms for the Development of a Gamified Emotion Regulation App
  NCT07159347 · Phase: Not specified · Ages: 8 Years to 12 Years · Sex: All (male and female) · 1 location
• Big Feelings: A Study on Children's Emotions in Therapy
  NCT05637320 · Phase: Not applicable (e.g. observational or device study) · Ages: 8 Years to 15 Years · Sex: All (male and female) · 2 locations
• Body Awareness in People With Depressive Disorder
  NCT06879977 · Phase: Not specified · Ages: 18 Years to 69 Years · Sex: All (male and female) · 1 location
• Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
  NCT05925322 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 80 Years · Sex: All (male and female) · 1 location
• Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders
  NCT07295652 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
  NCT05543083 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 17 Years · Sex: Female · 2 locations
• Comparing Brief Psychoanalytic Couple Therapy and Emotionally Focused Therapy in Reducing Relationship Distress
  NCT07100951 · Phase: Not applicable (e.g. observational or device study) · Ages: 24 Years to 65 Years · Sex: All (male and female) · 2 locations
• Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
  NCT05962879 · Phase: Not applicable (e.g. observational or device study) · Ages: 14 Years to 19 Years · Sex: All (male and female) · 1 location
• EL-SHIN Therapy for Depressive Symptoms
  NCT06995807 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Effectiveness of the Group Unified Protocol for Emotional Disorders in Adults in a Public Mental Health Setting
  NCT07682064 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study
  NCT07454070 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Enhancing Brain And Mental Health Through Breathing Practice
  NCT07369752 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 17 Years · Sex: All (male and female) · 2 locations
• Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles @Schule" (i Am Everything @school)
  NCT06668688 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles"
  NCT06668701 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Feasibility Study of UP-A-AST Parent Group for Adolescents With Autism and Co-occurring Anxiety/Depression
  NCT07637799 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years and older · Sex: All (male and female) · 2 locations
• Gut Microbiota in IBD With Comorbid Depressive Disorder
  NCT07252427 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition
  NCT07197138 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Improving Treatment for Depression in General Practice Using a Step-by-Step Care Plan.
  NCT07263321 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder
  NCT07191392 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 60 Years · Sex: All (male and female) · 2 locations
• Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
  NCT06511908 · Phase: Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Islamic-Oriented vs. Standard Ericksonian Hypnotherapy for Anxiety and Depression
  NCT06844058 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Ketamine Treatment Plans for Chronic Conditions
  NCT06038409 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice
  NCT07022184 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• M3VAS Validation in Polish Population
  NCT06412562 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression
  NCT07022171 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
  NCT07654179 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 4 locations
• Mindfulness Engaged Neurostimulation for Depression (MEND II)
  NCT07512284 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Music Therapy for Adolescents with Emotional Difficulties
  NCT06733883 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 18 Years · Sex: All (male and female) · 1 location
• OSU6162 as add-on in SSRI/SNRI-resistant Depression
  NCT05641623 · Phase: Phase 2 · Ages: 25 Years to 75 Years · Sex: All (male and female) · 4 locations
• Prediction on the Recurrence of Manic and Depressive Episodes in Bipolar Disorder
  NCT05828056 · Phase: Not specified · Ages: 20 Years to 60 Years · Sex: All (male and female) · 1 location
• Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression
  NCT06898606 · Phase: Phase 1, Phase 2 · Ages: 25 Years to 65 Years · Sex: All (male and female) · 1 location
• Psychological State, Immunotherapy Response, and Multi-Omics Signatures in TNBC
  NCT07290153 · Phase: Not specified · Ages: 18 Years to 70 Years · Sex: Female · 3 locations
• Study of the Neural Circuits Underlying the Negative Emotional Bias of Depressive Disorders and Their Response to Ketamine
  NCT06630065 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Study the Efficacy and Safety of the INtegral Cognitive REMediation Program (INCREM) for Depression
  NCT06590025 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
  NCT05786066 · Phase: Phase 2 · Ages: 21 Years to 65 Years · Sex: All (male and female) · 1 location
• The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study
  NCT06206226 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders
  NCT07458100 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity.
  NCT06901739 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Transcranial Direct Current Stimulation for Depression
  NCT06187454 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Transdiagnostic Internet-delivered Intervention for Adolescents With Anxiety and Depression
  NCT06724666 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 17 Years · Sex: All (male and female) · 2 locations
• Unified Protocol: Community Connections
  NCT06038721 · Phase: Not applicable (e.g. observational or device study) · Ages: 7 Years to 17 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Depressive Disorder often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Depressive Disorder trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.