Clinical trials recruiting for Down Syndrome

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome
  NCT06943170 · Phase: Not applicable (e.g. observational or device study) · Ages: 8 Years to 16 Years · Sex: All (male and female) · 1 location
• Brain Outcomes With Lifestyle Change in Down Syndrome
  NCT05985486 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 64 Years · Sex: All (male and female) · 2 locations
• Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
  NCT05231798 · Phase: Phase 2 · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Gamma Frequency Stimulation in Individuals With Down Syndrome
  NCT05196984 · Phase: Not applicable (e.g. observational or device study) · Ages: 25 Years to 65 Years · Sex: All (male and female) · 1 location
• GnRH Therapy on Cognition in Down Syndrome
  NCT04390646 · Phase: Phase 2, Phase 3 · Ages: 16 Years to 50 Years · Sex: All (male and female) · 1 location
• HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome
  NCT07296861 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 1 location
• LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
  NCT07234695 · Phase: Phase 3 · Ages: 40 Years and older · Sex: All (male and female) · 5 locations
• Patterns of Neurodevelopmental Disorders
  NCT06213090 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
  NCT04278404 · Phase: Not specified · Ages: 0 Years to 20 Years · Sex: All (male and female) · 52 locations
• Physical Activity and Community EmPOWERment Project
  NCT06740162 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Retinal Imaging in Neurodegenerative Disease
  NCT03233646 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• Trial-Ready Cohort-Down Syndrome (TRC-DS)
  NCT04165109 · Phase: Not specified · Ages: 25 Years to 55 Years · Sex: All (male and female) · 22 locations
• tDCS for Catatonic Depression in Down Syndrome: A Pilot Study
  NCT06866925 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Down Syndrome often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Down Syndrome trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.