Clinical trials recruiting for Heart Failure With Reduced Ejection Fraction
45
Recruiting trials
38
US states with sites
26
Countries
7%
Accept healthy volunteers
Phase breakdown
Drugs and treatments being studied
Where trials are recruiting (top US states)
| State | Recruiting trials |
|---|---|
| Virginia | 5 |
| Connecticut | 4 |
| Illinois | 4 |
| Pennsylvania | 4 |
| Texas | 4 |
| Arizona | 3 |
| California | 3 |
| Colorado | 3 |
| Florida | 3 |
| Massachusetts | 3 |
| Michigan | 3 |
| New York | 3 |
Top cities
New Haven, Connecticut 4Boston, Massachusetts 3Charlottesville, Virginia 3Cleveland, Ohio 3Houston, Texas 3Jacksonville, Florida 3New York, New York 3Philadelphia, Pennsylvania 3Salt Lake City, Utah 3Tucson, Arizona 3
Self-screener
Recruiting trials
- A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
- A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
- A Study Investigating the Impact of IMT With CR On Exercise Responses In HF
- Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
- Colchicine in Acutely Decompensated HFREF
- Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure
- Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG
- Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study
- Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction
- Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
- Digital Solutions in Heart Therapy (DIGNITY)
- Digital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 Study
- Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure
- Efficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® Software
- Empagliflozin in Heart Failure with Reduced Ejection Fraction and End Stage Renal Disease
- Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDication
- Feasibility and Effectiveness of Eccentric Exercise in Sarcopenic Older Adults with Heart Failure: a Pilot Study
- HFrEF Polypill in Sri Lanka RCT
- Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
- High Fat Diet for Cardiac Metabolic Reprogramming
- Home-Based Cardiac Rehabilitation for Patients With Heart Failure
- Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
- Improving CRT Outcome With Non-Invasive Cardiac Mapping
- Ketones, SGLT2, HFrEF
- Left vs Left Randomized Clinical Trial
- Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients
- Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
- Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
- Mobile Applet for Weight Management in Obese Heart Failure Patients
- PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction
- PRagmatic Study Of Messaging to Providers of Patients With Heart Failure in Amsterdam UMC
- Prediction of Heart-Failure with Machine Learning
- Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF
- Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
- Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF
- Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction
- STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart Failure
- Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Failure
- Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
- Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
- The CardioClip Study
- The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
- The Sarcopenia Study
- Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure
- Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy
Related conditions
Trials recruiting for Heart Failure With Reduced Ejection Fraction often also study these conditions. Each links to its own recruiting-trial list.
Heart failure 1021Heart Failure With Preserved Ejection Fraction 56Obesity 1512Hypertension 1201Heart Failure With Mid Range Ejection Fraction 4Pulmonary hypertension 95Cardiovascular Diseases 164Vascular Diseases 18Type2diabetes 24Type 2 diabetes 891
Common questions
Are these trials free to join?
Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.
How do I know if I am eligible for Heart Failure With Reduced Ejection Fraction trials?
Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.
Is this list complete?
No. For the full list, search ClinicalTrials.gov.