Clinical trials recruiting for Heart Failure With Preserved Ejection Fraction

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

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Recruiting trials

• A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction
  NCT07269717 · Phase: Phase 2 · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• A Preliminary Study for INFORMED
  NCT05585125 · Phase: Phase 4 · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
  NCT07214376 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 6 locations
• A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD
  NCT07093528 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure
  NCT07083011 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
  NCT07795814 · Phase: Phase 2 · Ages: 30 Years to 84 Years · Sex: All (male and female) · 25 locations
• Arterial Stiffening as a Predictor for Diastolic Cardiac Dysfunction and HFpEF
  NCT06208007 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Assessment of CCM in HF With Higher Ejection Fraction
  NCT05064709 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 105 locations
• Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillation (AF), Heart Failure and Preserved Ejection Fraction: Heart Rate Regularization Versus Medical Rate Control
  NCT06833138 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 17 locations
• BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching
  NCT07413198 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years and older · Sex: All (male and female) · 1 location
• Bariatric Surgery Evaluation and Assessment of Treatment Efficacy - Intervention Trial
  NCT06065124 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 70 Years · Sex: All (male and female) · 2 locations
• Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
  NCT05174351 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 80 Years · Sex: All (male and female) · 1 location
• Biomarkers in Patients With Suspected HFpEF
  NCT06101693 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatment in Patients With Heart Failure With Preserved Ejection Fraction
  NCT05508256 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
  NCT06409585 · Phase: Not specified · Ages: 30 Years to 90 Years · Sex: All (male and female) · 1 location
• EMPAgliflozin in Heart Failure With PReserved Ejection Fraction and End Stage Renal Disease
  NCT06249945 · Phase: Phase 4 · Ages: 20 Years and older · Sex: All (male and female) · 2 locations
• EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
  NCT07202000 · Phase: Phase 2 · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDication
  NCT06278844 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
  NCT07401771 · Phase: Not specified · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction
  NCT05582044 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)
  NCT06337812 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• HFPEF-project: Heart Failure Phenotyping - Exploring the Fingerprints
  NCT06465043 · Phase: Not specified · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)
  NCT07123779 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
  NCT05873634 · Phase: Not specified · Ages: 30 Years and older · Sex: All (male and female) · 6 locations
• Home-Based Cardiac Rehabilitation for Patients With Heart Failure
  NCT06479876 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Incretin Therapies in Obesity-related HFpEF
  NCT07554638 · Phase: Phase 4 · Ages: 40 Years and older · Sex: All (male and female) · 2 locations
• Ketogenic Diet vs Mixed Diet in Patients With Heart Failure
  NCT06081543 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
  NCT06388226 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Managing Congestion in Heart Failure: A Mechanistic Study in Patients With HFpEF
  NCT06977477 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction
  NCT06652763 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
  NCT07037459 · Phase: Phase 3 · Ages: 18 Years to 99 Years · Sex: All (male and female) · 1314 locations
• Matching Perfusion and Metabolic Activity in HFpEF
  NCT04913805 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
  NCT06061549 · Phase: Phase 1 · Ages: 50 Years and older · Sex: All (male and female) · 2 locations
• Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction
  NCT06785506 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 6 locations
• Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
  NCT06517186 · Phase: Not specified · Ages: 30 Years and older · Sex: All (male and female) · 6 locations
• Myocardial Stiffness Evaluation in Patients With Heart Failure With Preserved Ejection Fraction
  NCT06196086 · Phase: Not specified · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Novel Approaches for Improving Vascular Function in Veterans With HFpEF
  NCT06312748 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• PBMC as Biomarkers of Diabetic Cardiomyopathy
  NCT05651919 · Phase: Not specified · Ages: 40 Years to 85 Years · Sex: All (male and female) · 2 locations
• Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
  NCT05525663 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
  NCT05838287 · Phase: Phase 4 · Ages: 30 Years to 70 Years · Sex: All (male and female) · 1 location
• Provocative Tests for HFpEF
  NCT06309550 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Purinergic Signaling and the Postmenopausal Heart
  NCT06015776 · Phase: Not specified · Ages: 30 Years to 88 Years · Sex: All (male and female) · 1 location
• Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
  NCT04237701 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Renal Denervation in Patients With Chronic Heart Failure With Preserved Ejection Fraction
  NCT05715697 · Phase: Not applicable (e.g. observational or device study) · Ages: 21 Years to 80 Years · Sex: All (male and female) · 1 location
• Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
  NCT06652087 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
  NCT05057806 · Phase: Early Phase 1 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
  NCT05138575 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• SHort Of Pace - Heart Failure (SHOP-HF)
  NCT06992089 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
  NCT02901184 · Phase: Phase 3 · Ages: 50 Years to 99 Years · Sex: All (male and female) · 78 locations
• Study on Heart Failure with Preserved Ejection Fraction with Qishen Granules
  NCT06377761 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 2 locations
• Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
  NCT05723679 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years to 90 Years · Sex: All (male and female) · 1 location
• The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction
  NCT05878912 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 2 locations
• The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)
  NCT06702501 · Phase: Not applicable (e.g. observational or device study) · Ages: 30 Years and older · Sex: All (male and female) · 1 location
• The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
  NCT05490901 · Phase: Not specified · Ages: 19 Years and older · Sex: All (male and female) · 1 location
• The Sarcopenia Study
  NCT05888688 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Transitions of Care Clinic (TOCC)
  NCT06937827 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 90 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Heart Failure With Preserved Ejection Fraction often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Heart Failure With Preserved Ejection Fraction trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.