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18F-mFBG Imaging for Myocardial Sympathetic Innervation
NCT06965621 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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A Phase I/II Clinical Trial of Intramyocardial Injection of HucMSCs for the Treatment of Chronic Heart Failure
NCT07265349 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 4 locations
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A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction
NCT07269717 ·
Phase: Phase 2 ·
Ages: 40 Years and older ·
Sex: All (male and female) · 1 location
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A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
NCT06979375 ·
Phase: Phase 2 ·
Ages: 40 Years to 84 Years ·
Sex: All (male and female) · 92 locations
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A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
NCT06979362 ·
Phase: Phase 2 ·
Ages: 40 Years to 84 Years ·
Sex: All (male and female) · 117 locations
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A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure
NCT07083011 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
NCT07795814 ·
Phase: Phase 2 ·
Ages: 30 Years to 84 Years ·
Sex: All (male and female) · 25 locations
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A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity
NCT06862908 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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A Study of Metformin to Improve Cardiac Function After LVAD Implantation
NCT07666698 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 5 locations
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A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
NCT06991257 ·
Phase: Phase 2 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female) · 142 locations
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A Trial of CRD-4730 in HFrEF
NCT07750873 ·
Phase: Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female) · 2 locations
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AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
NCT06793371 ·
Phase: Phase 2 ·
Ages: 40 Years to 85 Years ·
Sex: All (male and female) · 26 locations
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Add-on Diuretics in Acute Decompensated Heart Failure
NCT07372040 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure
NCT06783166 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Atrial Shunt for the Treatment of Heart Failure With Reduced Ejection Fraction
NCT07820410 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVD
NCT03593317 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 13 locations
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CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation
NCT06762964 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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COgnitioN With VERiciGuat Evaluation in Heart Failure
NCT06601465 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 4 locations
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Canagliflozin in Advanced Renal Disease With MRI Endpoints
NCT06182839 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
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Cardiovascular Effects of SGLT2 Inhibitors in Hemodialysis Patients: A Phase 2 Randomized Study
NCT06929169 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female) · 1 location
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Cardiovascular Genistein Therapy for Heart Failure Inflammation
NCT06501768 ·
Phase: Phase 1, Phase 2 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female) · 1 location
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Cell Therapy and Myocardial Recovery in Heart Failure Patients Undergoing Left Ventricular Assist Device Support
NCT06154044 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female) · 1 location
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Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
NCT05485961 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1114 locations
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Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)
NCT07304817 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 4 locations
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Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction
NCT07560436 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Cyclosporine In Takotsubo Syndrome
NCT05946772 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 24 locations
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EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
NCT07202000 ·
Phase: Phase 2 ·
Ages: 40 Years and older ·
Sex: All (male and female) · 1 location
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Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure
NCT06423599 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage
NCT04696523 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 7 locations
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Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
NCT06130059 ·
Phase: Phase 2 ·
Ages: 50 Years and older ·
Sex: All (male and female) · 1 location
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Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
NCT05714085 ·
Phase: Phase 2, Phase 3 ·
Ages: 29 Days to 17 Years ·
Sex: All (male and female) · 109 locations
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Ertugliflozin in Chronic Heart Failure
NCT04438213 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
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Exogenous KETOne Supplements in Patients Hospitalized for Acute Heart Failure
NCT06653725 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 8 locations
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Exploratory Study of ADR-002K for Heart Failure Patients With Ischemic Heart Disease Who Undergo CABG
NCT07192211 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
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Feasibility Trial for a Right Ventricular Failure Platform Trial
NCT06570473 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 10 locations
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Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy
NCT06634108 ·
Phase: Phase 1, Phase 2 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female) · 1 location
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HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT07123779 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 3 locations
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Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body
NCT06645691 ·
Phase: Phase 2 ·
Ages: 21 Years to 99 Years ·
Sex: All (male and female) · 1 location
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Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation
NCT05450328 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients
NCT07695090 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
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Matching Perfusion and Metabolic Activity in HFpEF
NCT04913805 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Medication Withdrawal in Stable HF With Improved LVEF
NCT07489547 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
NCT06405555 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
NCT04703842 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 5 locations
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Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
NCT06080074 ·
Phase: Phase 2 ·
Ages: 0 Years to 16 Years ·
Sex: All (male and female) · 5 locations
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Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients
NCT05732051 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Female · 1 location
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Optimising Pacing for Contractility 2
NCT04201015 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Optimizing HFrEF Patients Using BaroStim and CardioMems
NCT07399587 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
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PET Myocardial Fatty-acid Metabolic Imaging With XTR003 Injection and 18F-FDG to Assess Myocardial Viability in Ischemic Cardiomyopathy
NCT07443696 ·
Phase: Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female) · 3 locations
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Peritoneal Ultrafiltration in Cardio Renal Syndrome.
NCT03994874 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 3 locations
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Phase II Clinical Study of HRS-9057 Injection in Patients With Heart Failure-induced Fluid Retention
NCT07318103 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Pilot Study: Interest of Belatacept as a Non-nephrotoxic Immunosuppressive Treatment in Cardiac Transplant Patients at Risk of Chronic Renal Failure (BELACOEUR)
NCT04180085 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 4 locations
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Polypill for Prevention of Cardiomyopathy
NCT06143566 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female) · 1 location
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Prevent Cardiac Surgery Associated AKI Trial
NCT06620523 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female) · 1 location
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Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
NCT04982419 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 3 locations
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Repurposing Valsartan May Protect Against Pulmonary Hypertension
NCT06053580 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
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Rilonacept in Subjects With Cardiac Sarcoidosis
NCT06660732 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 2 locations
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Roxadustat's Effect on Heart, Nutrition, and Inflammation in Hemodialysis Patients
NCT06903559 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
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SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
NCT05138575 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Safety and Efficacy of FAP iCDC in End-stage Dilated Cardiomyopathy
NCT06902896 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
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Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure
NCT04396899 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 3 locations
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Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction
NCT04680442 ·
Phase: Phase 2 ·
Ages: No age limits stated ·
Sex: All (male and female) · 8 locations
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Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
NCT07273838 ·
Phase: Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female) · 2 locations
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Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
NCT06435156 ·
Phase: Phase 2 ·
Ages: 18 Years to 84 Years ·
Sex: All (male and female) · 34 locations
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Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity
NCT06820099 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 2 locations
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Study to Assess Safety and Efficacy of Treating Symptomatic, Ischemic, Chronic Congestive Heart Failure Patients with an LVEF of ≤40% with Fresh, Uncultured, Autologous, Adipose-derived Regenerative Cells Isolated from Lipoaspirate.
NCT06705023 ·
Phase: Phase 2 ·
Ages: 21 Years to 80 Years ·
Sex: All (male and female) · 1 location
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Swedish Cardiac And Renal Failure Study-1
NCT07029503 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Tailored Exercise Training Study Among Adults With HFpEF
NCT07223242 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
The CARDIOPROTECT Trial
NCT07654426 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study
NCT06059664 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
NCT05562167 ·
Phase: Phase 2 ·
Ages: 19 Years to 79 Years ·
Sex: All (male and female) · 1 location
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The Treatment Effects of Empagliflozin on Renal Outcomes in Cardiorenal Syndrome Type 1
NCT06030843 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients
NCT03383419 ·
Phase: Phase 2 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female) · 3 locations
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Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
NCT05194111 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 120 Years ·
Sex: All (male and female) · 1 location
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Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer Patients
NCT07245069 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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Valganciclovir vs. Letermovir for CMV Prophylaxis in Heart Transplant
NCT07079735 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female) · 2 locations
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Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure
NCT06851949 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 5 locations
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Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy
NCT06128980 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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the Clinical Outcome of Empagliflozin in Pediatric Heart Failure Patients
NCT07692256 ·
Phase: Phase 2 ·
Ages: 1 Month to 18 Years ·
Sex: All (male and female) · 1 location