Phase 4 Heart failure trials recruiting now

All Heart failure trials, every phase

Other phases for Heart failure

Phase 4 Heart failure trials

• A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record
  NCT06642272 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 12 locations
• A Preliminary Study for INFORMED
  NCT05585125 · Phase: Phase 4 · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
  NCT06651970 · Phase: Phase 4 · Ages: 18 Years to 130 Years · Sex: All (male and female) · 23 locations
• Acetazolamide Per os for Decompensation of Heart Failure
  NCT05802849 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Allograft Dysfunction in Heart Transplant
  NCT03102125 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients With Assist Device
  NCT06655376 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatment in Patients With Heart Failure With Preserved Ejection Fraction
  NCT05508256 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Clinical Impact of SGLT2 Inhibitor After DC Cardioversion in Persistent AF With HFpEF
  NCT07776054 · Phase: Phase 4 · Ages: 19 Years and older · Sex: All (male and female) · 2 locations
• Clinical Study of Endocardial Myocardial Biopsy
  NCT05718128 · Phase: Phase 4 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of Macitentan and Dapagliflozin in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction (HFmrEF and HFpEF) and Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH)
  NCT07147114 · Phase: Phase 4 · Ages: 19 Years and older · Sex: All (male and female) · 30 locations
• Colchicine in Acutely Decompensated HFREF
  NCT06286423 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomes
  NCT06475105 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
  NCT06964464 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 13 locations
• DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure
  NCT05276219 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 5 locations
• DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis
  NCT07322237 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot Study
  NCT07572032 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 4 locations
• Digoxin After Acute Heart Failure (DIG-DICA)
  NCT07321509 · Phase: Phase 4 · Ages: 18 Years to 120 Years · Sex: All (male and female) · 1 location
• Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts
  NCT06218199 · Phase: Phase 4 · Ages: 19 Years and older · Sex: All (male and female) · 1 location
• EMPAgliflozin in Heart Failure With PReserved Ejection Fraction and End Stage Renal Disease
  NCT06249945 · Phase: Phase 4 · Ages: 20 Years and older · Sex: All (male and female) · 2 locations
• ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement
  NCT05672836 · Phase: Phase 4 · Ages: 19 Years and older · Sex: All (male and female) · 31 locations
• Effect of Empagliflozin on Quality of Life in Chronic Heart Failure Patients With Diabetes Mellitus Type II
  NCT06706791 · Phase: Phase 4 · Ages: 40 Years to 70 Years · Sex: All (male and female) · 1 location
• Effect of Enavogliflozin on Recurrence of Atrial Fibrillation After Catheter Ablation
  NCT06528262 · Phase: Phase 4 · Ages: 19 Years to 84 Years · Sex: All (male and female) · 1 location
• Effect of INtravenous FERRic Carboxymaltose Onmortality and Cardiovascular Morbidity, and Quality of Life in Iron Deficient Patients With Recent Myocardial infarCTion
  NCT05759078 · Phase: Phase 4 · Ages: 18 Years to 90 Years · Sex: All (male and female) · 43 locations
• Effect of Oral sucRosomIal Iron on exerciSE Capacity and Quality of Life in Patients With Heart Failure
  NCT06270498 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Effect of the Use of Dapagliflozin in Patients With Refractory Heart Failure
  NCT06578520 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Effects of SGLT2 Inhibitors in Pre-heart Failure Populations With Hypertension
  NCT06055452 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 4 locations
• Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With Congenital Heart Disease
  NCT06260059 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With Heart Failure
  NCT07397650 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 21 locations
• Empagliflozin in Heart Failure with Reduced Ejection Fraction and End Stage Renal Disease
  NCT06249932 · Phase: Phase 4 · Ages: 20 Years and older · Sex: All (male and female) · 4 locations
• Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction
  NCT07178145 · Phase: Phase 4 · Ages: 18 Years to 90 Years · Sex: All (male and female) · 1 location
• Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening Heart Failure
  NCT06979726 · Phase: Phase 4 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Incretin Therapies in Obesity-related HFpEF
  NCT07554638 · Phase: Phase 4 · Ages: 40 Years and older · Sex: All (male and female) · 2 locations
• Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure
  NCT07577596 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Landiolol in Mitral Valve Surgery
  NCT06793670 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 13 locations
• Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
  NCT07490067 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload
  NCT06166654 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 5 locations
• PVP-Guided Decongestive Therapy in HF 2
  NCT06495892 · Phase: Phase 4 · Ages: 18 Years to 99 Years · Sex: All (male and female) · 16 locations
• Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention
  NCT04899479 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
  NCT05838287 · Phase: Phase 4 · Ages: 30 Years to 70 Years · Sex: All (male and female) · 1 location
• Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions
  NCT07617376 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
  NCT07527156 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• SHengXIaN-QuYu DEcoction in Heart Failure With Reduced and Mildly Reduced Ejection Fraction
  NCT05583773 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 26 locations
• STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart Failure
  NCT07631156 · Phase: Phase 4 · Ages: 19 Years and older · Sex: All (male and female) · 5 locations
• Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From Rural Tanzania
  NCT06704633 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)
  NCT05465031 · Phase: Phase 4 · Ages: 18 Years and older · Sex: Female · 8 locations
• Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study
  NCT04191681 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure
  NCT07259512 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Study to Evaluate the Efficacy of Immunosuppression in Myocarditis or Inflammatory Cardiomyopathy.
  NCT04654988 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission.
  NCT07513883 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The Danish Warfarin-Dialysis Study - Safety and Efficacy of Warfarin in Patients With Atrial Fibrillation on Dialysis
  NCT03862859 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 13 locations
• The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure
  NCT07482943 · Phase: Phase 4 · Ages: 12 Years and older · Sex: All (male and female) · 2 locations
• The Effect of Dapagliflozin on Patients With Cardiomyopathy
  NCT07076615 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The Effects of Low-Dose Versus High-Dose Intravenous IRON Therapy With Ferric DerisomaltOSE in Patients With Chronic Heart Failure and Iron Deficiency
  NCT06427343 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The Prevalence of Iron Deficiency and the Effectiveness of Ferinject® in Patients With HFpEF (ID-HFpEF)
  NCT05793996 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The STOP-MED CTRCD Trial
  NCT06183437 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 14 locations
• Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing
  NCT07281014 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
  NCT07263035 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Vericiguat and Reverse Remodeling Indices in Heart Failure
  NCT07405944 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location

Common questions

What does Phase 4 mean?

See how clinical trials work.

Is this list complete?

No. For the full record, search ClinicalTrials.gov.