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A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
NCT07218029 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
NCT06742723 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Bridgeville, Butler, Exton, Langhorne
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A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.
NCT07222917 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Media
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A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects
NCT06843577 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh, Washington
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A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients
NCT07076303 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Plymouth Meeting
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A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
NCT07214376 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Pennsylvania: Mechanicsburg
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A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)
NCT07175038 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma
NCT06822738 ·
Phase: Phase 3 ·
Ages: 45 Years and older ·
Sex: All (male and female)
· Pennsylvania: Bala-Cynwyd, Philadelphia
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A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)
NCT07481981 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
NCT06649110 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia
NCT06408181 ·
Phase: Phase 3 ·
Ages: 18 Years to 45 Years ·
Sex: Female
· Pennsylvania: Philadelphia
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Advanced Neuroimaging in Idiopathic Intracranial Hypertension
NCT06950099 ·
Phase: Not specified ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis
NCT03630211 ·
Phase: Phase 2 ·
Ages: 8 Years to 60 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
NCT06059638 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Doylestown, Lancaster, Philadelphia
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Caffeine Consumption in Glaucoma Patients and Healthy Subjects
NCT03675412 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
NCT06482853 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Pennsylvania: Hershey
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Clarifying the Optimal Application of SLT Therapy Trial
NCT04967989 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Kingston, Philadelphia, Pittsburgh
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Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia
NCT06281756 ·
Phase: Early Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Hershey, Pittsburgh
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Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)
NCT06826859 ·
Phase: Phase 1, Phase 2 ·
Ages: 16 Years to 55 Years ·
Sex: Female
· Pennsylvania: Philadelphia
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DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
NCT06388421 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Bethlehem, Philadelphia
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EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
NCT07064473 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Beaver, Camp Hill, Philadelphia, Pittsburgh
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Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
NCT06468202 ·
Phase: Phase 4 ·
Ages: 14 Years to 35 Years ·
Sex: Female
· Pennsylvania: Pittsburgh
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Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
NCT07179380 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Feasibility of Semaglutide in Advanced Lung Disease
NCT05746039 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Global Paradise System US Post Approval Study
NCT06297291 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Harrisburg, Phildelphia
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Hydrus® Microstent New Enrollment Post-Approval Study
NCT04553523 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years and older ·
Sex: All (male and female)
· Pennsylvania: Cranberry Township
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LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
NCT07288398 ·
Phase: Phase 3 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Pennsylvania: Allentown, Pittsburgh, Wynnewood
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Mobile Health Program for Post-Preeclampsia Hypertension
NCT07599579 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female
· Pennsylvania: Pittsburgh
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Mobile Health Program for Rural Hypertension
NCT05546931 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
NCT06911632 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Non-Invasive Preeclampsia Screening and Biobank
NCT06643741 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: Female
· Pennsylvania: Danville, Philadelphia
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Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal
NCT05470205 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Novel Glaucoma Diagnostics
NCT00286637 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
NCT06274801 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
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Optimizing Prescribing Decisions for Hospitalized Older Adults With Chronic Conditions
NCT06605807 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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PET Image in PAH Patients
NCT05452889 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry
NCT02249923 ·
Phase: Not specified ·
Ages: 1 Day to 21 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Penn Medicine Healthy Heart
NCT06062394 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 35 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
NCT04278404 ·
Phase: Not specified ·
Ages: 0 Years to 20 Years ·
Sex: All (male and female)
· Pennsylvania: Hershey
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Prospective Validation of the Novel PVD-B65 Risk Score in Patients With Chronic Lung Disease and Pulmonary Hypertension
NCT07151768 ·
Phase: Not specified ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Pulmonary Hypertension Association Registry
NCT04071327 ·
Phase: Not specified ·
Ages: 0 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
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Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension
NCT07209254 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female
· Pennsylvania: Philadelphia
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SHAPE of Portal Hypertension in Children
NCT04720456 ·
Phase: Phase 2 ·
Ages: 6 Years to 21 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Safety and Effectiveness of the VisiPlate Aqueous Shunt in Patients With Refractory Open-Angle Glaucoma
NCT07220876 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Sleep Promotion and Pediatric Hypertension
NCT06642246 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years to 18 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories
NCT07041281 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Female
· Pennsylvania: Pittsburgh
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Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma
NCT07228221 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
NCT05587712 ·
Phase: Phase 2 ·
Ages: 1 Year to 17 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
NCT06559891 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: Lancaster, Philadelphia
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The Venous Distension Reflex and Orthostatic Hypertension
NCT03496792 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Hershey
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To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension
NCT06343298 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Treatment With Aspirin After Preeclampsia: TAP Trial
NCT06281665 ·
Phase: Phase 4 ·
Ages: 18 Years to 55 Years ·
Sex: Female
· Pennsylvania: Pittsburgh
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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NCT06526195 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Abington, Hershey, Philadelphia, Pittsburgh
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Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass
NCT07132788 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
NCT07181109 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Camp Hill, Horsham, Linwood, Media
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iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH
NCT05442671 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 8 Years to 18 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia