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A Beta-only IL-2 ImmunoTherapY Study
NCT05086692 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Boca Raton
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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
NCT07070232 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Sarasota, Tampa
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A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
NCT06022029 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tamarac
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A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
NCT06150664 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Margate, Orlando, Sarasota
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A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
NCT05914116 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Celebration, Margate, Orlando, Plantation
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A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
NCT06581406 ·
Phase: Phase 2, Phase 3 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Florida: Jacksonville, Miami
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A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors
NCT05970497 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Weston
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A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
NCT06246916 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Clermont, Jacksonville, Tamarac, Tampa
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A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies
NCT05669430 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Fort Myers
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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
NCT06172478 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Kissimmee
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A Study of IBI363 in Subjects with Advanced Solid Malignancies
NCT06281678 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Ocala, Plantation
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A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
NCT06362369 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Lake Mary
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A Study of VET3-TGI in Patients With Solid Tumors
NCT06444815 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Miami
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A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
NCT05592626 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Celebration, Miami
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A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
NCT04511013 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Aventura, Coral Gables, Deerfield Beach, Miami
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A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
NCT04913285 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville, Orlando
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A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
NCT05824975 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
NCT05361174 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Florida: Miami, Orlando, Tampa
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A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
NCT06326411 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
NCT05538130 ·
Phase: Phase 1 ·
Ages: 16 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
NCT05355701 ·
Phase: Phase 1 ·
Ages: 16 Years and older ·
Sex: All (male and female)
· Florida: Miami
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A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma
NCT06624644 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
NCT03686124 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Miami
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Adjuvant Quisinostat in High-Risk Uveal Melanoma
NCT06932757 ·
Phase: Phase 2 ·
Ages: 19 Years and older ·
Sex: All (male and female)
· Florida: Miami
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Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma
NCT04741997 ·
Phase: Early Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
NCT06418204 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Clearwater, Plant City, St. Petersburg, Tampa
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At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
NCT05969860 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
NCT05136196 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma
NCT06961357 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Florida: Aventura, Bonita Springs, Clearwater, Deerfield Beach
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Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
NCT06265285 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
NCT06953089 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Florida City
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DESTINY-PANTUMOUR04
NCT07124000 ·
Phase: Not specified ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· Florida: Coral Springs, St. Petersburg, West Palm Beach
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DermaSensor Postmarket Surveillance Study
NCT06666790 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Florida: New Smyrna Beach
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Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
NCT03567889 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patients
NCT04562129 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
NCT06112314 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville, Miami
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Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
NCT05896839 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Aventura, Coral Gables, Deerfield Beach, Miami
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Integrated Cancer Repository for Cancer Research
NCT02012699 ·
Phase: Not specified ·
Ages: 19 Years to 110 Years ·
Sex: All (male and female)
· Florida: Daytona Beach, DeLand, Orange City, Palm Coast
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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
NCT05655312 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Florida: Jacksonville, Miami, Sarasota
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MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
NCT05076760 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
NCT03860883 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Aventura, Coral Gables, Coral Springs, Deerfield Beach
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Neoadjuvant Darovasertib in Primary Uveal Melanoma
NCT07015190 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville, Tampa
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Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma
NCT06295159 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Nodal Radiation Therapy for Sentinel Lymph Node Positive Melanoma
NCT04594187 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization
NCT05264974 ·
Phase: Phase 1 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Florida: Gainesville
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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Hollywood, Lakeland
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Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease
NCT06529822 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Orlando
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Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
NCT05269381 ·
Phase: Phase 1, Phase 2 ·
Ages: 16 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
NCT04787042 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma
NCT07276386 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Project: Every Child for Younger Patients With Cancer
NCT02402244 ·
Phase: Not specified ·
Ages: Up to 25 Years ·
Sex: All (male and female)
· Florida: Fort Lauderdale, Fort Myers, Gainesville, Hollywood
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SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
NCT06743126 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville, Miami, Orlando, Tampa
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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Florida: Jacksonville, Miami, Tampa
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Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
NCT06697301 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Hialeah
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Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
NCT06047379 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Boynton Beach
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Safety and Efficacy of OBX-115 in Advanced Solid Tumors
NCT06060613 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Orlando
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Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
NCT05267626 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Miami
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Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma
NCT06121180 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
NCT04198766 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Clermont, Orange City
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Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
NCT06585410 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Coral Springs, Delray Beach, Tampa
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Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
NCT05379985 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma
NCT06627244 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Miami
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Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
NCT05727904 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Florida: Orlando
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TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
NCT04485013 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Daytona Beach, Fleming Island, Ocala, Orlando
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Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
NCT05549297 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville, Orlando
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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
NCT06500455 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Aventura, Boca Raton, Coral Gables, Deerfield Beach
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The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
NCT07285044 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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The Florida ASCENT Study
NCT07042243 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Florida: Gainesville
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VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
NCT06264180 ·
Phase: Phase 3 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Florida: Hollywood, Jacksonville, Tampa