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A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors
NCT05932862 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer
NCT07644559 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
NCT06881992 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations
NCT06906562 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Minneapolis, Rochester
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A Prospective Registry for Patients at High-Risk for Pancreatic Cancer
NCT06151223 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT04657068 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Maple Grove, Rochester
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A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
NCT07492680 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
NCT06172478 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Saint Louis Park, Saint Paul
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A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
NCT07213791 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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A Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT04389632 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Coon Rapids, Minneapolis, Saint Paul
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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
NCT07522073 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Maple Grove
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A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
NCT07409272 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Minneapolis, Saint Louis Park, Saint Paul
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A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
NCT06330064 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Minneapolis
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A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
NCT06051695 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
NCT06989437 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
NCT04858334 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Bemidji, Coon Rapids, Duluth, Minneapolis
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Adenovirus (RGDCRAdCOX2F)
NCT06693986 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Minneapolis
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Axelopran for Advanced Cancer in Patients Receiving Opioids
NCT07354919 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Saint Louis Park, Saint Paul
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BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma
NCT07226856 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
NCT06651580 ·
Phase: Not specified ·
Ages: Up to 17 Years ·
Sex: All (male and female)
· Minnesota: Minneapolis
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Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen
NCT07087054 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Minnesota: Aitkin, Albert Lea, Baxter, Bemidji
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Collecting Medical Information and Tissue Samples From Patients With Pancreatic Cancer or Other Pancreatic Disorders
NCT00830557 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
NCT04239573 ·
Phase: Not specified ·
Ages: 50 Years to 75 Years ·
Sex: All (male and female)
· Minnesota: Bemidji, Rochester, Thief River Falls, Worthington
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Evaluation of a Mixed Meal Test for Diagnosis and Characterization and Type 3c Diabetes Mellitus Secondary to Pancreatic Cancer and Chronic Pancreatitis (DETECT)
NCT03460769 ·
Phase: Not specified ·
Ages: 30 Years to 84 Years ·
Sex: All (male and female)
· Minnesota: Minneapolis, Rochester
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Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis
NCT04858009 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Minnesota: Rochester
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Integrated Cancer Repository for Cancer Research
NCT02012699 ·
Phase: Not specified ·
Ages: 19 Years to 110 Years ·
Sex: All (male and female)
· Minnesota: Aitkin, Brainerd, Duluth, Fergus Falls
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Investigational Scan (68Ga-FAPI-46 PET/CT) for Imaging of Cancer-Associated Fibroblasts for Localized Pancreatic Ductal Adenocarcinoma
NCT05518903 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration
NCT06973564 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
NCT06026410 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
NCT06073431 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Burnsville, Coon Rapids, Edina, Maple Grove
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Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula
NCT06807437 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Aitkin, Baxter, Brainerd, Crosslake
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Lead-212 PSV359 Therapy for Patients With Solid Tumors
NCT06710756 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Minnesota: Rochester
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Medical Cannabis in Patients With Advanced Pancreatic and Colorectal Cancer
NCT06605430 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Saint Louis Park
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Molecular Detection of Advanced Neoplasia in Pancreatic Cysts
NCT03855800 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 120 Years ·
Sex: All (male and female)
· Minnesota: Rochester
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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
NCT06271291 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
NCT06562192 ·
Phase: Phase 1 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female)
· Minnesota: Rochester
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Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
NCT06411795 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Minneapolis
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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Minnesota: Duluth
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Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
NCT04981119 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
NCT06005493 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
NCT07252232 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
NCT05254171 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Saint Cloud
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Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy
NCT05477576 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
NCT05005403 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Minneapolis
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Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients
NCT06922591 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations
NCT06998940 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Aitkin, Baxter, Brainerd, Crosslake
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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
NCT04851119 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Months to 30 Years ·
Sex: All (male and female)
· Minnesota: Minneapolis
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Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
NCT06958328 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Bemidji
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Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
NCT05040360 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Aitkin, Baxter, Brainerd, Burnsville
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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
NCT06943755 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Minnesota: Rochester
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cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881 ·
Phase: Not specified ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Minnesota: Minneapolis, Rochester