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A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
NCT06925737 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
NCT06863272 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer
NCT04729114 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Bala-Cynwyd
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A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
NCT06778863 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer
NCT06095089 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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A Study of LY4257496 in Participants With Cancer (OMNIRAY)
NCT07114601 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
NCT06952803 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Hershey, Lancaster, Pittsburgh
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A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
NCT06136650 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Bala-Cynwyd, Philadelphia
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A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
NCT06395519 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer
NCT05818683 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT07225946 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Allentown, Bala-Cynwyd, Hershey, Pittsburgh
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A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)
NCT07164443 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Bala-Cynwyd, Lancaster, Philadelphia, Pittsburgh
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A Study of SYNC-T Therapy SV-102 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT06533644 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia, Pittsburgh
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A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide
NCT06844383 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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A Study of Tarlatamab for People With Prostate Cancer
NCT07111507 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer
NCT06457919 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
NCT04104776 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
NCT07213674 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Pittsburgh
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A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
NCT06764485 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Allentown, Philadelphia, Willow Grove
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A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer
NCT05125016 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors
NCT03972657 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
NCT07611110 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Pittsburgh
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Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.
NCT05422911 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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Adaptive Radiation Therapy for Men With Intermediate- or High-Risk Prostate Cancer
NCT07219303 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment
NCT06235697 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Erie, Jefferson Hills, Monroeville, Pittsburgh
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Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test
NCT05629494 ·
Phase: Phase 4 ·
Ages: 18 Years to 80 Years ·
Sex: Male
· Pennsylvania: Hershey
-
Carboplatin or Olaparib for BRcA Deficient Prostate Cancer
NCT04038502 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
Circulating Tumor DNA in High Risk Localized Prostate Cancer
NCT07222436 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Pittsburgh
-
Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy
NCT07234968 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Pennsylvania: Allentown, Bethlehem, Danville, East Stroudsburg
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Customized TULSA-PRO Ablation Registry
NCT05001477 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: York
-
DESTINY-PANTUMOUR04
NCT07124000 ·
Phase: Not specified ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer
NCT05804318 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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Distance-Based Exercise to Preserve Function and Prevent Disability
NCT07059884 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Butler, Indiana, New Castle, Pittsburgh
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Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
NCT06592924 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Chadds Ford, Danville, Dickson City, Hazleton
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Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564 ·
Phase: Phase 4 ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female)
· Pennsylvania: Hershey, Philadelphia
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Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer
NCT06613100 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network
NCT05627219 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
FOG-001 in Locally Advanced or Metastatic Solid Tumors
NCT05919264 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh
-
FTT PET/CT in Metastatic Prostate Cancer
NCT05242744 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
First-Time-in-Human Study of GSK5471713 in Adults With mCRPC
NCT07332455 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer
NCT06517901 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Hershey
-
Hypofractionated WPPT With HDR Boost
NCT06591819 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
NCT03151629 ·
Phase: Not specified ·
Ages: 21 Years and older ·
Sex: Male
· Pennsylvania: Doylestown, Philadelphia, West Reading
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Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
NCT05803941 ·
Phase: Phase 4 ·
Ages: 18 Years to 100 Years ·
Sex: Male
· Pennsylvania: Pittsburgh
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Metastatic Castrate-Resistant Prostate Cancer Subjects Treated With PROVENGE® + One Infusion of Sipuleucel-T
NCT06134232 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Bala-Cynwyd, Lancaster
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Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
NCT06780670 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 100 Years ·
Sex: Male
· Pennsylvania: Philadelphia
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PSMA PET Combined With MRI for the Detection of PCa
NCT07052214 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
Patient Navigation Program to Improve Clinical Trial Enrollment in Cancer Patients
NCT06138067 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Chambersburg
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Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation
NCT05487846 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study
NCT04472338 ·
Phase: Not specified ·
Ages: 40 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
Prostate Specific Membrane Antigen (PSMA) or (FACBC) PET/CT Site-Directed Therapy for Treatment of Prostate Cancer, Flu-BLAST-PC Study
NCT04175431 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Pittsburgh
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Prostate Tissue BioBank
NCT06659614 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT
NCT01885299 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Pennsylvania: Danville, Philadelphia, Pottstown
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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
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Sacral Neuromodulation for Male Overactive Bladder (MOAB)
NCT06511141 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Bala-Cynwyd
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Safety and Efficacy of AGN-INM176 in Prostate Patients With Rising PSA
NCT06600698 ·
Phase: Phase 1, Phase 2 ·
Ages: 40 Years and older ·
Sex: Male
· Pennsylvania: Hershey
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Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
NCT05283330 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
NCT03678025 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Chambersburg, Danville, Ephrata, Gettysburg
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Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer
NCT07140900 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia, Pittsburgh
-
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT04221542 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia, Pittsburgh
-
Study of AZD0754 in Participants With Metastatic Prostate Cancer
NCT06267729 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 130 Years ·
Sex: Male
· Pennsylvania: Philadelphia
-
Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation
NCT04890613 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
Study of DCC-2812 in Participants With Advanced Genitourinary Cancers
NCT06966024 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
NCT05519449 ·
Phase: Phase 1 ·
Ages: 18 Years to 100 Years ·
Sex: Male
· Pennsylvania: Hershey, Philadelphia, Pittsburgh
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Study of ORIC-944 in Patients With Metastatic Prostate Cancer
NCT05413421 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Bala-Cynwyd, Lancaster
-
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
NCT06136624 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
Study of Oral MRT-2359 With Apalutamide in Prostate Cancer
NCT07745361 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Lancaster
-
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
NCT06545942 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia
-
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
NCT05176483 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Hershey, Philadelphia, Pittsburgh
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TERPS Trial for de Novo Oligometastic Prostate Cancer
NCT05223803 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia, Pittsburgh
-
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
NCT04485013 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
NCT06632977 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Sayre
-
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
NCT05946213 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Beaver, Carlisle, Chadds Ford, Chambersburg
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Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body
NCT06470243 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Allentown, Bethlehem, Chadds Ford, East Stroudsburg
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Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial
NCT06931340 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Erie, Jefferson Hills, Monroeville, Natrona Heights
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Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
NCT03866382 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Allentown, Bethlehem, East Stroudsburg, Erie
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The CArdiovascular Risk Evaluation in Men With Prostate Cancer Study (CARE-PC) Pilot Feasibility Study
NCT06064149 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
NCT04585750 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Pennsylvania: Philadelphia, Pittsburgh, York
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The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
NCT04075305 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Pennsylvania: Pittsburgh
-
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
NCT07028853 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Bala-Cynwyd, Lancaster
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Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
NCT04423211 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Altoona, Beaver, Broomall, Carlisle
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Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer
NCT07493512 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia, Pittsburgh
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Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
NCT04787744 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Philadelphia
-
Virtual Reality Headset and/or Aromatherapy for Patients Undergoing a Transperineal Prostate Biopsy
NCT06296147 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Male
· Pennsylvania: Pittsburgh
-
Vitamin D for Prostate Endocrine Therapy
NCT05838716 ·
Phase: Phase 3 ·
Ages: 50 Years and older ·
Sex: Male
· Pennsylvania: Dickson City, Scranton, Wilkes-Barre