Clinical trials recruiting for Systemic Sclerosis (SSc)

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Clinical Study of TI-0032-III Injection in Patients With Relapsed and Refractory Autoimmune Diseases
  NCT07413341 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• A Clinical Study of YTS109 Cell for R/R Autoimmune Diseases
  NCT07104721 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• A Clinical Study of YTS109 Cell in R/R Autoimmune Diseases
  NCT06978647 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101
  NCT07403188 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
  NCT06308978 · Phase: Phase 1 · Ages: 12 Years to 70 Years · Sex: All (male and female) · 21 locations
• A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy
  NCT06249438 · Phase: Phase 1 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• A Study of OL-108 in Relapsed/Refractory Autoimmune Diseases
  NCT06980597 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
  NCT06991114 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 52 locations
• Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
  NCT07507201 · Phase: Early Phase 1 · Ages: 3 Years and older · Sex: All (male and female) · 1 location
• Anti-CD19 IL-10/IL15 CAR-NK Cells in Refractory/Relapsed Autoimmune Diseases
  NCT06614270 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
  NCT06794008 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease
  NCT07305116 · Phase: Phase 1 · Ages: 3 Years and older · Sex: All (male and female) · 1 location
• CAR T-cell Therapy Targeting CD19 and BCMA in Patients With Relapse/Refractory Autoimmune Diseases
  NCT06941129 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• CD19/BCMA UCAR-T for B Cell-Related Autoimmune Disease
  NCT07586267 · Phase: Early Phase 1 · Ages: 3 Years and older · Sex: All (male and female) · 1 location
• CT1190B in the Treatment of Patients With Moderate to Severe Refractory Systemic Lupus Erythematosus (SLE) or Refractory/Progressive Systemic Sclerosis (SSc)
  NCT06822881 · Phase: Phase 1 · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
  NCT07150000 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Controlling Hyperactive Immunity With Long-lived Lymphocytes
  NCT07473154 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 10 locations
• FT839 in Autoimmune Diseases
  NCT07800871 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Home-Based Clinical Management of Cardiac Complications in Systemic Sclerosis
  NCT06865118 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Interferon Signature in Anti-CTLA-4 and Anti-PD-1/PD-L1-Treated Cancer Patients Compared With Systemic Autoimmune Disease Patients
  NCT07249060 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• MTS109 in Patients With Refractory Autoimmune Diseases
  NCT07526350 · Phase: Early Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Multicenter Study on the Development of Pulmonary Arterial Hypertension Screening Models Based on Artificial Intelligence for Patients With Systemic Sclerosis
  NCT07236970 · Phase: Not specified · Ages: 18 Years to 80 Years · Sex: All (male and female) · 5 locations
• Phase 1 Study of HBI0101 CAR-T in Refractory B-Cell Autoimmune Diseases
  NCT07085676 · Phase: Phase 1 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 2 locations
• Rare AutoImmune SElf-management Programme Development
  NCT06642870 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Safety Study of CC312 in Autoimmune Disease Patients
  NCT06888960 · Phase: Early Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Autoimmune Diseases
  NCT06828042 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases
  NCT07087912 · Phase: Phase 4 · Ages: 12 Years to 59 Years · Sex: All (male and female) · 4 locations
• US Zamto-cel Autoimmune Diseases
  NCT06708845 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Systemic Sclerosis (SSc) often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Systemic Sclerosis (SSc) trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.