Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Recruiting · NCT06363981 · Interventional (participants receive a specific treatment) · Lead sponsor: Jakub Antczak
View the official record on ClinicalTrials.gov →Interventions studied
Active rTMS over the left DLPFCActive rTMS over the left DLPFC and over the left DMPFCSham rTMS
What this trial is about
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat. rTMS is a relatively novel treatment option, whose therapeutic potential is still investigated and optimized. The aim of this study is to assess the effect of rTMS applied over two stimulation sites on cognitive impairment, anhedonia and sleep disorders in depression.
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- severe or moderate depressive episode (according to international classification of diseases (ICD)-10) without psychotic symptoms at the time of inclusion
- Hamilton Depression Rating Scale between between 20 and 35 points at inclusion
- The score in the Athens Insomnia Scale eight or more
- The score of three or more points in items 4 and 21 of the Beck Depressions Inventory 2
- Complaining about problems with memory and concentration timely related with the onset of depression
Exclusion criteria
- Contraindications to transcranial magnetic stimulation, including ferromagnetic elements in head, pregnancy and epilepsy
- Psychotic symptoms at the time of inclusion
- Suicidal ideations and/or attempts within three months prior to inclusion
Where it is running
1 location listed.
- The Education of Research and Development Center, Babinski Clinical Hospital - Krakow, Poland