An Innovative Master Platform for Clinical Trials in Mood Disorders
Recruiting · NCT06408012 · Observational (researchers observe without assigning treatment) · Lead sponsor: St. Joseph's Healthcare Hamilton
View the official record on ClinicalTrials.gov →What this trial is about
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person. Repeated efforts to find the right treatment contribute to poor functioning, low quality of life, and prolongs the time it takes to get well. Most areas of medicine are able to use 'biomarkers' or clinical tests, blood tests, or imaging to help diagnose and treat illness. The search for biomarkers in mood disorders is advancing, but one roadblock to progress is the lack of large, standardized studies of mood disorders that are needed to accurately identify biomarkers. The aim of the ENABLE platform is to provide the Canadian neuroscience community a standardized way of collecting biomarker data from individuals with a range of mood disorders symptoms. In addition, this 'master clinical trial platform' framework will provide a pool of participants who can be recruited into biomarker-based clinical trials.
Who can take part
Inclusion criteria
- Patients:
- 16 years of age or older.
- Meet criteria for bipolar or depressive disorders as defined by DSM-5.
- Fluency in English, sufficient to complete the interviews and self-report questionnaires.
- Inclusion Criteria
- Healthy Comparison (HC) Participants:
- 16 years of age or older.
- No history of psychiatric disorders (according to DSM-5) or significant unstable medical conditions.
- Fluency in English, sufficient to complete the interviews and self-report questionnaires.
Where it is running
9 locations listed.
- University of Calgary - Calgary, Alberta, Canada
- University of British Columbia - Vancouver, British Columbia, Canada
- Nova Scotia Health Authority - Halifax, Nova Scotia, Canada
- McMaster University - Hamilton, Ontario, Canada
- Queen's University - Kingston, Ontario, Canada
- University of Ottawa - Ottawa, Ontario, Canada
- University Health Network - Toronto, Ontario, Canada
- Centre for Addiction and Mental Health - Toronto, Ontario, Canada
- Ontario Shores Centre for Mental Health Sciences - Whitby, Ontario, Canada