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A Phase 1/1b Study of IAM1363 in HER2 Cancers
NCT06253871 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City, St Louis
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A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
NCT07020221 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)
NCT07058012 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT04657068 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
NCT06750094 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
NCT06662786 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
NCT03526835 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)
NCT07011576 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia
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A Study of LY4257496 in Participants With Cancer (OMNIRAY)
NCT07114601 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
NCT07213791 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of PHN-012 in Patients With Advanced Solid Tumors
NCT07127874 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
NCT07549412 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia
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A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
NCT03093116 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Missouri: Bolivar, St Louis
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A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
NCT06440005 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
NCT06820463 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City
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A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
NCT06682793 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
NCT06051695 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
NCT07221357 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City, St Louis
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A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
NCT07094204 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
NCT06562543 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City, St Louis
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AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
NCT07094113 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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CARE Tool Study Aim 3
NCT07296887 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Rolla, St Louis
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Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
NCT04354064 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer
NCT06696768 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Creve Coeur, St Louis
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Missouri: Ballwin, Bolivar, Branson, Cape Girardeau
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ColoSense Post-Approval Study
NCT07069556 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
NCT05174169 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Ballwin, Bolivar, Branson, Cape Girardeau
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Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
NCT05612347 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 65 Years to 82 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain
NCT06848348 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Fenton
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Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer
NCT03516708 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
NCT05552755 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
NCT07018869 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Ballwin, Bolivar, Branson, Cape Girardeau
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FOG-001 in Locally Advanced or Metastatic Solid Tumors
NCT05919264 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer
NCT07446322 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Family Communications After Genetic Testing
NCT07143487 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Ballwin, Bolivar, Branson, Cape Girardeau
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Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
NCT05080673 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years to 70 Years ·
Sex: All (male and female)
· Missouri: Ballwin, Bolivar, Branson, Cape Girardeau
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IDOV-Immune for Advanced Solid Tumors
NCT06910657 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid
NCT06910670 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Integrated Cancer Repository for Cancer Research
NCT02012699 ·
Phase: Not specified ·
Ages: 19 Years to 110 Years ·
Sex: All (male and female)
· Missouri: Kansas City, Liberty, North Kansas City, Saint Joseph
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JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration
NCT06973564 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
NCT06026410 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
NCT06073431 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Farmington, Osage Beach, Sainte Genevieve, Springfield
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Lead-212 PSV359 Therapy for Patients With Solid Tumors
NCT06710756 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
NCT03998202 ·
Phase: Not specified ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Missouri: Cape Girardeau, Farmington, Rolla, Saint Joseph
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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
NCT06205485 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
NCT06625775 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Kansas City, St Louis
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Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors
NCT05856981 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
NCT06218914 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
NCT05786924 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
NCT06950385 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
NCT07228832 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Springfield
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Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)
NCT07327489 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Springfield, St Louis
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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Missouri: Kansas City, St Louis
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Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
NCT04981119 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
NCT07030257 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer
NCT07527858 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors
NCT06974110 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
NCT05855200 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Joplin, St Louis
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Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)
NCT06462183 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
NCT06252649 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Bridgeton
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Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
NCT07283939 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Ballwin, Bolivar, Branson, Cape Girardeau
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TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
NCT04485013 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
NCT04851119 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Months to 30 Years ·
Sex: All (male and female)
· Missouri: St Louis
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Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
NCT05234177 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Joplin, Springfield, St Louis
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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
NCT05863195 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Creve Coeur, St Louis
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Testing for Safety and Colorectal Cancer Preventive Effects of ONC201
NCT05630794 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study
NCT05673148 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia, Farmington, Saint Joseph, Sainte Genevieve
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Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers
NCT05803382 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Creve Coeur, St Louis
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Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness
NCT05691491 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: City of Saint Peters, Creve Coeur, Kansas City, Lee's Summit
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Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers
NCT02838836 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia
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Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
NCT03551951 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: Columbia
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Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer
NCT04339374 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 19 Years and older ·
Sex: All (male and female)
· Missouri: St Louis
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Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)
NCT06340646 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Missouri: St Louis