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A New Intervention to Improve Function in Veterans With Anxiety and Depression
NCT06188923 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Durham
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A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
NCT07115329 ·
Phase: Phase 2 ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female)
· North Carolina: Raleigh
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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NCT03887715 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Cary, Raleigh, Winston-Salem
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A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
NCT07172516 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· North Carolina: Charlotte
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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
NCT06775379 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· North Carolina: Charlotte
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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
NCT07076407 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· North Carolina: Cary
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A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
NCT07573176 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· North Carolina: Cary
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A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
NCT04777357 ·
Phase: Phase 3 ·
Ages: 10 Years to 17 Years ·
Sex: All (male and female)
· North Carolina: Kinston
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A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
NCT06223880 ·
Phase: Phase 4 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Hickory
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A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT07196501 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Charlotte
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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
NCT07284667 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Cary
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ALTO-207 in Adults With Treatment-resistant Depression (TRD)
NCT07553637 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· North Carolina: Charlotte
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Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
NCT06538246 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Durham
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Adolescent Mood During Puberty and Testosterone
NCT06072677 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 11 Years to 14 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Allopregnanolone (Zuranolone) in Post-stroke Depression
NCT06759558 ·
Phase: Phase 2 ·
Ages: 21 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Durham
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CARED : A Novel Rapid Treatment Paradigm for Depression
NCT07507370 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
NCT05663034 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Fort Bragg
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Collaborative Care for Anxiety and Depression in Epilepsy
NCT05559749 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Winston-Salem
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Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking
NCT07050355 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years and older ·
Sex: All (male and female)
· North Carolina: Durham
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Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults
NCT06060860 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Depression, Aging, Stress and Heart Health Study
NCT05570721 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 44 Years to 55 Years ·
Sex: Female
· North Carolina: Chapel Hill
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E-Mindfulness Approaches for Living After Breast Cancer
NCT06748222 ·
Phase: Phase 3 ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· North Carolina: Albemarle, Asheboro, Burlington, Charlotte
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Effects of "Alliance180 Program" on Well-Being
NCT06451523 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Enhancing Slow Wave Sleep in Depression
NCT07143838 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female)
· North Carolina: Winston-Salem
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Examining the Effects of Estradiol on Neural and Molecular Response to Reward
NCT05282277 ·
Phase: Phase 4 ·
Ages: 45 Years to 55 Years ·
Sex: Female
· North Carolina: Chapel Hill
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Identifying and Treating Depression in the Orthopaedic Trauma Population
NCT05976347 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Winston-Salem
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Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer
NCT06636721 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 60 Years and older ·
Sex: All (male and female)
· North Carolina: Durham
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NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06963021 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Charlotte
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Neuroscience of Psychotherapy for Depression
NCT06696001 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 30 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit
NCT07173205 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 15 Years to 39 Years ·
Sex: All (male and female)
· North Carolina: Greenville, Winston-Salem
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Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
NCT06610305 ·
Phase: Phase 4 ·
Ages: 18 Years to 45 Years ·
Sex: Female
· North Carolina: Chapel Hill
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Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
NCT06559306 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· North Carolina: Hickory
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Project neuroARTEMIS
NCT06814275 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 59 Years ·
Sex: All (male and female)
· North Carolina: Winston-Salem
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RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
NCT07002034 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families
NCT06627764 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 12 Years to 100 Years ·
Sex: All (male and female)
· North Carolina: Durham
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Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
NCT05851898 ·
Phase: Phase 4 ·
Ages: 65 Years and older ·
Sex: All (male and female)
· North Carolina: Winston-Salem
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Study of ALTO-300 in MDD
NCT05922878 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· North Carolina: Hickory
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Supporting Health in Veterans With Heart Failure
NCT05839067 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· North Carolina: Durham
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TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
NCT07048574 ·
Phase: Not specified ·
Ages: 18 Months to 11 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)
NCT06587230 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 5 Years to 99 Years ·
Sex: All (male and female)
· North Carolina: Chapel Hill
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Telehealth Music Therapy for Adults With Endocrine Disorder and Depression
NCT07413874 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· North Carolina: Boone