-
129 Xenon Imaging in Patients Treated With Sotatercept
NCT06351345 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
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129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)
NCT06104228 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
129Xe MRI Cardiopulmonary
NCT06038630 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
2-HOBA in Systemic Lupus Erythematosus
NCT07225543 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Female · 1 location
-
A Multicenter, Prospective, Randomized, Open-label Phase Ib/II Study of Celecoxib Plus Pembrolizumab and Gemcitabine/Cisplatin Versus Pembrolizumab and Gemcitabine/Cisplatin in Patients With CK5/6-High Unresectable Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma
NCT07632235 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
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A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Uncontrolled Hypertension
NCT07654140 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
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A Phase II Trial of G01 Eye Drops for Glaucomatous Optic Neuropathy
NCT07777861 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 9 locations
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A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.
NCT07222917 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 71 locations
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A Phase Ⅰb/Ⅱa Clinical Study of IMC-003 Injection for the Treatment of Pulmonary Arterial Hypertension Receiving Background Therapy.
NCT07593027 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 29 locations
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A Prospective Phase II Study of Postoperative Concurrent Chemoradiotherapy in Patients With Intrahepatic Cholangiocarcinoma
NCT07063888 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
A Study of BEBT-701 in Patients With Mild to Moderate Hypertension and Elevated Low-Density Lipoprotein Cholesterol（LDL-C）
NCT07368608 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female) · 2 locations
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A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults
NCT07143448 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 4 locations
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A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
NCT07142356 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female) · 24 locations
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A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD
NCT07333183 ·
Phase: Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female) · 13 locations
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A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)
NCT07175038 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 23 locations
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A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032)
NCT07646860 ·
Phase: Phase 2 ·
Ages: 1 Year to 17 Years ·
Sex: All (male and female) · 3 locations
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A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran
NCT07553442 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 3 locations
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A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia
NCT07610278 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 58 locations
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A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
NCT06649110 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female) · 87 locations
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A Trial Evaluating Safety, Tolerability and Efficacy of CTX340 in Participants With Hypertension
NCT07758634 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 2 locations
-
A Trial of "APL-9796'' in Adults With Pulmonary Hypertension
NCT06846554 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 6 locations
-
A Trial of Apatinib and Adebrelimab in Combination With Chemotherapy in Patients With Unresectable ICC
NCT06925516 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)
NCT05201144 ·
Phase: Phase 2 ·
Ages: No age limits stated ·
Sex: All (male and female) · 1 location
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Additional Chemotherapy Administered Directly Into the Liver Using a Chemo Pump in Patients With Bile Duct Cancer Inside the Liver Treatable by Surgery
NCT06888063 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Aspirin for Postpartum Patients With Preeclampsia
NCT05924971 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Female · 1 location
-
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis
NCT03630211 ·
Phase: Phase 2 ·
Ages: 8 Years to 60 Years ·
Sex: All (male and female) · 3 locations
-
Bioenergetic Effect of Pioglitazone in CLD-PH
NCT06336798 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH
NCT05937854 ·
Phase: Phase 2 ·
Ages: 35 Years to 89 Years ·
Sex: All (male and female) · 5 locations
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CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH
NCT06947460 ·
Phase: Phase 1, Phase 2 ·
Ages: 10 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia
NCT07238400 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: Female · 2 locations
-
Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding
NCT04499898 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients
NCT06991712 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Cryoablation Combined With Lenvatinib Plus QL1706 (Iparomlimab/Tuvonralimab) in Patients With Advanced Intrahepatic Cholangiocarcinoma
NCT07070700 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
DIAG723 in Adults With Hereditary Hemorrhagic Telangiectasia
NCT07623525 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 11 locations
-
Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)
NCT06826859 ·
Phase: Phase 1, Phase 2 ·
Ages: 16 Years to 55 Years ·
Sex: Female · 1 location
-
EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION
NCT06462287 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
EUS Guided Portal-systemic Pressure Gradient Measurement
NCT04633356 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
Effect of Dexmedetomidine on Hemodynamic Response to Endotracheal Intubation in Hypertensive Patients
NCT06712186 ·
Phase: Phase 1, Phase 2 ·
Ages: 60 Years and older ·
Sex: All (male and female) · 1 location
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Effects of Metformin on Hepatic Venous Pressure Gradient in Patients With Cirrhosis and Portal Hypertension
NCT06687265 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Effects of an Antioxidant Supplement on Blood Vessel Health
NCT06424756 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
Efficacy and Safety of SPC1001 in Patients With Essential Hypertension
NCT06826872 ·
Phase: Phase 2 ·
Ages: 19 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
Endocalyx in Treatment Resistent Hypertension
NCT06940011 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Endothelin-1 Receptor Blockade in Resistant Hypertension
NCT04388124 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial
NCT07267260 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
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Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
NCT07090161 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female) · 28 locations
-
FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control
NCT07332741 ·
Phase: Phase 2 ·
Ages: No age limits stated ·
Sex: All (male and female) · 8 locations
-
Feasibility Trial for a Right Ventricular Failure Platform Trial
NCT06570473 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 10 locations
-
Feasibility of Semaglutide in Advanced Lung Disease
NCT05746039 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
GVB-2001 Gene Therapy Via Intracameral Injection for the Treatment of Primary Open Angle Glaucoma
NCT06921317 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT07123779 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 3 locations
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Hepatic Arterial Infusion Chemotherapy (HAIC) Combined With Durvalumab and Lenvatinib in Patients With Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma: a Phase 2 Study(HAIC-quad Trial)
NCT06859684 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
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LAM-001 for the Treatment of Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
NCT05798923 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 3 locations
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Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma
NCT03206060 ·
Phase: Phase 2 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female) · 1 location
-
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
NCT07183384 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 50 Years ·
Sex: Female · 1 location
-
Metformin as a Neuroprotective Therapy for Glaucoma
NCT05426044 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn
NCT04898114 ·
Phase: Phase 1, Phase 2 ·
Ages: 6 Hours to 72 Hours ·
Sex: All (male and female) · 1 location
-
Nesiritide in Hypertension
NCT02608996 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female) · 3 locations
-
Neurovascular Transduction During Exercise in Chronic Kidney Disease
NCT02947750 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 6 locations
-
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
NCT03821623 ·
Phase: Phase 2 ·
Ages: 50 Years and older ·
Sex: All (male and female) · 1 location
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PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
NCT05286814 ·
Phase: Phase 2 ·
Ages: 18 Years to 120 Years ·
Sex: All (male and female) · 1 location
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PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
NCT04971720 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
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Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
NCT07075718 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 3 locations
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Phase II Clinical Study of GemOX Hepatic Arterial Infusion Combined with Lenvatinib and Toripalimab for Advanced and Unresectable Intrahepatic Cholangiocarcinoma and Gallbladder Cancer
NCT06852287 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
-
Polypill for Prevention of Cardiomyopathy
NCT06143566 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female) · 1 location
-
Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia
NCT02989025 ·
Phase: Phase 2 ·
Ages: 18 Years to 45 Years ·
Sex: Female · 1 location
-
Prophylactic Endoscopic Variceal Ligation in Patients With High-risk Esophageal Varices Receiving Atezo/Bev for HCC
NCT06819566 ·
Phase: Phase 2 ·
Ages: 19 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
Pulmonary Hypertension SOLAR
NCT04778046 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders
NCT06333652 ·
Phase: Phase 2 ·
Ages: 18 Years to 50 Years ·
Sex: Female · 1 location
-
Repurposing Valsartan May Protect Against Pulmonary Hypertension
NCT06053580 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
SGLT2i Improve Left Atrial Function in Patients With Paroxysmal Atrial Fibrillation, Hypertension and Abnormal Glucose Metabolism
NCT07482020 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
SHAPE of Portal Hypertension in Children
NCT04720456 ·
Phase: Phase 2 ·
Ages: 6 Years to 21 Years ·
Sex: All (male and female) · 1 location
-
Safety and Efficacy of TimoD Sustained-Release Implant in Participants With Glaucoma or Ocular Hypertension Undergoing Cataract Surgery
NCT07036510 ·
Phase: Phase 1, Phase 2 ·
Ages: 40 Years and older ·
Sex: All (male and female) · 1 location
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Sildinafil in Pulmonary Hypertension-Rheumatic Chronic Valvular Disease(RCT)
NCT07462260 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Single-site Pilot Study Evaluating the Effect of QLS-111 Ophthalmic Solution on Posterior Perfusion and Vessel Dilation
NCT07354477 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Spironolactone for Pulmonary Arterial Hypertension
NCT01712620 ·
Phase: Phase 2 ·
Ages: 18 Years to 100 Years ·
Sex: All (male and female) · 1 location
-
Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories
NCT07041281 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Female · 3 locations
-
Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
NCT07098975 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Female · 2 locations
-
Study SOLACE SEPSIS
NCT06634069 ·
Phase: Phase 2 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female) · 1 location
-
Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
NCT07511361 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 11 locations
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Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)
NCT07318597 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 27 locations
-
Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease
NCT07473700 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 16 locations
-
Study to Evaluate Safety and Efficacy of Mirivadelgat in PH-ILD (Windward)
NCT06475781 ·
Phase: Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female) · 9 locations
-
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
NCT05587712 ·
Phase: Phase 2 ·
Ages: 1 Year to 17 Years ·
Sex: All (male and female) · 35 locations
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Sympathetic Mechanisms in Obesity-Crossover Design
NCT05312892 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female) · 2 locations
-
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
NCT04715022 ·
Phase: Phase 1, Phase 2 ·
Ages: 35 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
TIPS Plus Cadonilimab in Advanced HCC with Tumor Thrombosis-associated Portal Hypertension:a Prospective, Single-arm, Phase II Study
NCT05882370 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
TIPS Plus Half-dose Donafenib in AHCC with PVTT-associated Portal Hypertension
NCT06646198 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
Targeting Endoplasmic Reticulum Stress in Human Hypertension
NCT06025630 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
The Effect of Additive On-Demand Sildenafil vs. Dextrose Candy on Maximum Exercise Capacity in Pulmonary Arterial Hypertension
NCT07824674 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
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To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension
NCT06343298 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 29 locations
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Toripalimab Combined With Gemcitabine and Cisplatin (GemCis) as Preoperative Neoadjuvant Therapy for Resectable Intrahepatic Cholangiocarcinoma
NCT06721286 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Transdermal Microneedle Lignocaine Delivery Versus EMLA Patch for Topical Analgesia Before Venepuncture Procedure To Adults in Clinical Setting
NCT05694858 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.
NCT06947473 ·
Phase: Phase 1, Phase 2 ·
Ages: 6 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project
NCT06004674 ·
Phase: Phase 2 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female) · 1 location
-
Xenon MRI Pulm Hypertension
NCT04991454 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 1 location