Melanoma trials recruiting in California

All Melanoma trials nationally

Cities in California

Recruiting trials in California

• A Beta-only IL-2 ImmunoTherapY Study
  NCT05086692 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: San Diego, San Francisco, Santa Monica
• A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)
  NCT06961006 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco
• A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
  NCT07070232 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco
• A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
  NCT06022029 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles
• A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
  NCT06413680 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, San Francisco
• A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors
  NCT07584226 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, San Francisco
• A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors
  NCT06956690 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla
• A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
  NCT05914116 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Santa Monica
• A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
  NCT06581406 · Phase: Phase 2, Phase 3 · Ages: No age limits stated · Sex: All (male and female) · California: La Jolla, Los Angeles, Palo Alto
• A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors
  NCT05970497 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Rancho Santa Margarita
• A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
  NCT06246916 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: Fullerton, Los Alamitos, Los Angeles, Orange
• A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
  NCT04895709 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Clovis, Los Angeles, Newport Beach
• A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
  NCT07492680 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco
• A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma
  NCT06594991 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Stanford
• A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies
  NCT05669430 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles
• A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
  NCT06172478 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte
• A Study of IBI363 in Subjects with Advanced Solid Malignancies
  NCT06281678 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco
• A Study of MGC026 in Participants With Advanced Solid Tumors
  NCT06242470 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles
• A Study of NX-1607 in Adults With Advanced Malignancies
  NCT05107674 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte, Los Angeles, San Francisco
• A Study of VET3-TGI in Patients With Solid Tumors
  NCT06444815 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Orange
• A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
  NCT05592626 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Sacramento
• A Study of mRNA-4106 or mRNA-4200 Administered Alone or in Combination With Anti-Cancer Agents in Participants With Solid Tumors
  NCT06880549 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles
• A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information
  NCT07621614 · Phase: Not applicable (e.g. observational or device study) · Ages: Up to 25 Years · Sex: All (male and female) · California: Oakland
• A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3
  NCT06887348 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla
• A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
  NCT04511013 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Burbank, Dublin, Emeryville, Los Angeles
• A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
  NCT04913285 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, San Diego, San Francisco
• A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
  NCT06330064 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Whittier
• A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
  NCT05361174 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · California: Los Angeles
• A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
  NCT06326411 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco, Westwood, Los Angeles
• A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
  NCT05538130 · Phase: Phase 1 · Ages: 16 Years and older · Sex: All (male and female) · California: Los Angeles, Pasadena, San Francisco, Santa Monica
• A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma
  NCT06624644 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: Newport Beach, San Francisco, Stanford
• ACTengine® IMA203 Combined With mRNA-4203
  NCT06946225 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco
• ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
  NCT03686124 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Stanford
• Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
  NCT06418204 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · California: Antioch, Arroyo Grande, Carmichael, Dublin
• BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
  NCT04752826 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte
• BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
  NCT05136196 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Beverly Hills, Irvine, Los Angeles, Orange
• Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma
  NCT04598009 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, San Francisco
• BostonGene and Exigent Genomic INsight Study
  NCT06272864 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · California: Stockton
• Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
  NCT05334069 · Phase: Not specified · Ages: 40 Years to 75 Years · Sex: All (male and female) · California: Arroyo Grande, Bakersfield, Burbank, Carmichael
• Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
  NCT05297734 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte, Fresno, Fruitdale, Fullerton
• DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
  NCT06953089 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles
• DESTINY-PANTUMOUR04
  NCT07124000 · Phase: Not specified · Ages: 18 Years to 130 Years · Sex: All (male and female) · California: San Diego
• DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma
  NCT07288112 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte
• Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
  NCT03567889 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Orange
• Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors
  NCT07628634 · Phase: Early Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Orange
• Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
  NCT04119024 · Phase: Phase 1 · Ages: 18 Years to 75 Years · Sex: All (male and female) · California: Duarte, Los Angeles, Stanford
• Genetic Basis of Melanocytic Nevi
  NCT03054584 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · California: Sacramento
• IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
  NCT06112314 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Los Angeles, Palo Alto, Santa Monica
• Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
  NCT05896839 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Los Angeles
• Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma
  NCT05428007 · Phase: Phase 2 · Ages: 18 Years to 100 Years · Sex: All (male and female) · California: Los Angeles
• Intratumoral N17350 in Advanced Solid Tumors
  NCT07339176 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, San Francisco
• MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
  NCT05655312 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 90 Years · Sex: All (male and female) · California: Orange
• Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
  NCT03860883 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · California: Irvine, Los Angeles, Orange, Palo Alto
• Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma
  NCT06771544 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Orange
• Mirdametinib in Patients With Advanced NF1-mutant Melanoma
  NCT07237100 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco
• Narrow Excision Versus Wide Excision for the Treatment of Adults With Invasive Cutaneous Melanoma, ICEMAN Trial
  NCT06673095 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · California: Davis
• Navigation Intervention for Adolescent and Young Adult Cancer Survivors
  NCT07406087 · Phase: Not applicable (e.g. observational or device study) · Ages: 21 Years to 45 Years · Sex: All (male and female) · California: Pasadena
• Neoadjuvant Darovasertib in Primary Uveal Melanoma
  NCT07015190 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Los Angeles, Orange, Palo Alto
• ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
  NCT05059444 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Newport Beach, Redwood City, Sacramento
• Pan-tumor MRD Study
  NCT06605404 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · California: San Diego
• Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab
  NCT06249048 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Beverly Hills
• Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma
  NCT05830058 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte, Irvine
• Project: Every Child for Younger Patients With Cancer
  NCT02402244 · Phase: Not specified · Ages: Up to 25 Years · Sex: All (male and female) · California: Downey, Duarte, Loma Linda, Long Beach
• Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
  NCT06580002 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Orange
• SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
  NCT06743126 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte, La Jolla, Los Angeles, San Francisco
• SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
  NCT03452774 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · California: Duarte, Irvine, La Jolla, Orange
• Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
  NCT06697301 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Santa Rosa
• Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
  NCT06047379 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Beverly Hills, Glendale, Los Angeles
• Safety and Efficacy of OBX-115 in Advanced Solid Tumors
  NCT06060613 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Stanford
• Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors
  NCT06425926 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Bakersfield, Fullerton, Los Angeles, San Francisco
• Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer
  NCT05877430 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Irvine
• Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors
  NCT07287917 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Los Angeles, San Francisco
• Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies
  NCT04282044 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Stanford
• Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma
  NCT06121180 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles
• Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
  NCT03947385 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, San Francisco
• Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
  NCT04198766 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Duarte, Glendale, Los Angeles, Murrieta
• Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
  NCT06585410 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: La Jolla, Oceanside, Redwood City, Visalia
• Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
  NCT05379985 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Orange, Santa Monica
• Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
  NCT05727904 · Phase: Phase 3 · Ages: 18 Years to 70 Years · Sex: All (male and female) · California: Duarte, Los Angeles, San Francisco
• Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma
  NCT07148245 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · California: San Francisco
• TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
  NCT04485013 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles, Newport Beach
• Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
  NCT04851119 · Phase: Phase 1, Phase 2 · Ages: 12 Months to 30 Years · Sex: All (male and female) · California: Los Angeles, Orange, Palo Alto, San Francisco
• Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
  NCT06500455 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · California: Anaheim, Bellflower, Corona, Duarte
• The Multicentre Selective Lymphadenectomy Trial - 3
  NCT07049276 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · California: Los Angeles
• Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases
  NCT06712927 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · California: Palo Alto
• VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
  NCT06264180 · Phase: Phase 3 · Ages: 12 Years and older · Sex: All (male and female) · California: La Jolla, Los Angeles, Orange, Palo Alto