-
A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors
NCT05932862 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Germantown, Nashville
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A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
NCT07020221 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer
NCT07644559 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
NCT06695845 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Knoxville, Nashville
-
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
NCT03394365 ·
Phase: Phase 3 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Tennessee: Memphis, Nashville
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A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations
NCT06906562 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Knoxville, Memphis, Nashville
-
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT04657068 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Chattanooga, Memphis, Nashville
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A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
NCT04895709 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
NCT06778863 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
NCT06172478 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
NCT07277413 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
NCT06465069 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
NCT07066657 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
NCT05877599 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of PHN-012 in Patients With Advanced Solid Tumors
NCT07127874 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
NCT06914128 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT04389632 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
NCT07522073 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
NCT06179160 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
NCT06440005 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
NCT05941507 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
NCT06330064 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Chattanooga, Germantown, Nashville
-
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
NCT06051695 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations
NCT06835569 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
NCT07090499 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
NCT06760819 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies
NCT04503265 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
NCT04678648 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
NCT07094113 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
NCT04858334 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Collierville, Memphis
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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
NCT07562152 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Germantown, Nashville
-
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
NCT06917079 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
NCT04924075 ·
Phase: Phase 2 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
CT-95 in Advanced Cancers Associated With Mesothelin Expression
NCT06756035 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Tennessee: Germantown
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Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
NCT04239573 ·
Phase: Not specified ·
Ages: 50 Years to 75 Years ·
Sex: All (male and female)
· Tennessee: Knoxville, Memphis, Nashville
-
DESTINY-PANTUMOUR04
NCT07124000 ·
Phase: Not specified ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· Tennessee: Nashville
-
Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response
NCT04588025 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 19 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
NCT06239194 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)
NCT05431270 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Familial Investigations of Childhood Cancer Predisposition
NCT03050268 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Tennessee: Memphis
-
Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients
NCT00899626 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Increasing Germline Genetic Testing for Patients With Cancer
NCT07307664 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: No age limits stated ·
Sex: All (male and female)
· Tennessee: Nashville
-
Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC
NCT03257033 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
NCT06026410 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula
NCT06807437 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Knoxville, Memphis
-
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06586515 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Pancreatic Cancer Early Detection Consortium
NCT04970056 ·
Phase: Not specified ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Tennessee: Knoxville
-
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
NCT06218914 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT
NCT01885299 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Tennessee: Chattanooga
-
Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma
NCT07259317 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Tennessee: Memphis, Nashville
-
Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy
NCT06937177 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Memphis, Nashville
-
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors
NCT05732831 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
NCT04981119 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase
NCT04195347 ·
Phase: Phase 1, Phase 2 ·
Ages: Up to 21 Years ·
Sex: All (male and female)
· Tennessee: Memphis
-
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
NCT07252232 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
NCT07491445 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
NCT06128551 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
NCT05254171 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
NCT06545942 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
NCT05379985 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Chattanooga, Nashville
-
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06040541 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy
NCT05477576 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.
NCT07165132 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
NCT04429542 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
NCT04900818 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
NCT06084481 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations
NCT06998940 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Collierville, Memphis
-
Surgical Debulking Prior to Peptide Receptor Radionuclide Therapy in Well Differentiated Gastroenteropancreatic Neuroendocrine Tumors
NCT06016855 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
NCT04851119 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Months to 30 Years ·
Sex: All (male and female)
· Tennessee: Memphis
-
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
NCT06958328 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Collierville, Memphis
-
Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
NCT04172532 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Nashville
-
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
NCT05040360 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Alcoa, Collierville, Knoxville, Memphis
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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
NCT06943755 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Tennessee: Knoxville, Nashville
-
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881 ·
Phase: Not specified ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Tennessee: Memphis, Nashville