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A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia
NCT07459647 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Watertown
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A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
NCT06929442 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 30 Years ·
Sex: All (male and female)
· Massachusetts: Charlestown
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A Study of Brenipatide in Adult Participants With Schizophrenia
NCT07410507 ·
Phase: Phase 2 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· Massachusetts: Belmont, Watertown, Worcester
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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
NCT06585787 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston, North Dartmouth, South Dartmouth
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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)
NCT07288567 ·
Phase: Phase 3 ·
Ages: 13 Years to 17 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Worcester
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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively
NCT07424404 ·
Phase: Phase 3 ·
Ages: 5 Years to 17 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Lexington, Worcester
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Biomarkers to Enhance Early Schizophrenia Treatment
NCT06969755 ·
Phase: Phase 4 ·
Ages: 18 Years to 35 Years ·
Sex: All (male and female)
· Massachusetts: Belmont
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Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services
NCT06740383 ·
Phase: Not specified ·
Ages: 18 Years to 40 Years ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston
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CLOZAPINE Response in Biotype-1
NCT04580134 ·
Phase: Phase 4 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Cerebellar Modulation of Cognition in Psychosis
NCT06107764 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston
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Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
NCT07359157 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Worcester
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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
NCT05962879 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 14 Years to 19 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Efficacy of NBI-1117568 in Preventing Relapse in Adults With Schizophrenia
NCT07227818 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Enhanced Coordinated Specialty Care for Early Psychosis
NCT06071858 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: No age limits stated ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston, Cambridge, Worcester
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Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)
NCT07101094 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston, South Dartmouth
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Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
NCT06221852 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: All (male and female)
· Massachusetts: Belmont
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Metabolic Effects of Adjunctive Lumateperone Treatment in Clozapine-Treated Patients With Schizophrenia
NCT06174116 ·
Phase: Phase 4 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Worcester
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MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
NCT06191965 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 35 Years ·
Sex: All (male and female)
· Massachusetts: Belmont
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NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
NCT06963034 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Watertown
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NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia
NCT07114874 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston, Watertown
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Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
NCT04940663 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· Massachusetts: Charlestown
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Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations
NCT05299749 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· Massachusetts: Brockton
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Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
NCT05184335 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
NCT06376734 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Study of ALTO-101 in Patients With Schizophrenia
NCT06502964 ·
Phase: Phase 2 ·
Ages: 21 Years to 55 Years ·
Sex: All (male and female)
· Massachusetts: Belmont
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The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
NCT06386588 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: All (male and female)
· Massachusetts: Charlestown
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Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
NCT04296604 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia
NCT05343598 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· Massachusetts: Belmont