Clinical trials recruiting for Cognitive Decline

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
  NCT06411561 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
  NCT05877196 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
  NCT03657745 · Phase: Not specified · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
  NCT06733714 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
  NCT06627894 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 2 locations
• Biomarker Exploration in Aging, Cognition and Neurodegeneration
  NCT03860857 · Phase: Phase 3 · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
  NCT05277558 · Phase: Not specified · Ages: 12 Years to 17 Years · Sex: All (male and female) · 2 locations
• Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
  NCT05014399 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Cognitive Screening and Multidomain Intervention Targeting Cognitive Decline in Type 2 Diabetes (The Brain Care Study)
  NCT07250789 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years and older · Sex: All (male and female) · 3 locations
• Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
  NCT04800588 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 89 Years · Sex: All (male and female) · 1 location
• Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
  NCT03954899 · Phase: Not applicable (e.g. observational or device study) · Ages: 56 Years to 85 Years · Sex: All (male and female) · 1 location
• Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
  NCT06669546 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 85 Years · Sex: All (male and female) · 1 location
• Glucose Variability and Cognition in Prediabetes
  NCT04201600 · Phase: Not specified · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• GnRH Therapy on Cognition in Down Syndrome
  NCT04390646 · Phase: Phase 2, Phase 3 · Ages: 16 Years to 50 Years · Sex: All (male and female) · 1 location
• Investigating Neurocognitive Disorders Epidemiology
  NCT06375213 · Phase: Not specified · Ages: 35 Years and older · Sex: All (male and female) · 1 location
• Long-Term Effects of Walnut Consumption on Brain Function
  NCT07422220 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 75 Years · Sex: All (male and female) · 1 location
• MIND Foods and Aerobic Training in Black Adults With HTN
  NCT06152614 · Phase: Not applicable (e.g. observational or device study) · Ages: 35 Years to 75 Years · Sex: All (male and female) · 1 location
• MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients with Multiple Sclerosis
  NCT04806568 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
  NCT06727773 · Phase: Phase 2 · Ages: 18 Years and older · Sex: Female · 1 location
• Microbiota Mediated Flavonoid Metabolites for Cognitive Health
  NCT07226674 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Older Breast Cancer Patients: Risk for Cognitive Decline
  NCT03451383 · Phase: Not specified · Ages: 60 Years to 105 Years · Sex: Female · 1 location
• Polyphenols and Cognitive Decline
  NCT06507254 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
  NCT05339438 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes
  NCT04583800 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Preventing Cognitive Decline by Reducing BP Target Trial
  NCT05106036 · Phase: Not applicable (e.g. observational or device study) · Ages: 70 Years and older · Sex: All (male and female) · 1 location
• Sleep Impairment in Subjects at Risk of Developing Alzheimer's Disease
  NCT05649514 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 85 Years · Sex: All (male and female) · 1 location
• TMS for Cognitive Decline in Aging and Preclinical AD
  NCT06956300 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 99 Years · Sex: All (male and female) · 1 location
• TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics.
  NCT07399418 · Phase: Not specified · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
  NCT05988385 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years to 85 Years · Sex: All (male and female) · 4 locations
• The Peripheral Blood Multi-Omics Study on Sleep Loss
  NCT06492109 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• δ in Dementia Clinical Trials
  NCT05592678 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 100 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Cognitive Decline often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Cognitive Decline trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.