Clinical trials recruiting for Mild cognitive impairment

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Feasiblity Study of Green Activity Program for People Living With Memory Challenges
  NCT06403345 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years and older · Sex: All (male and female) · 1 location
• A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
  NCT05877196 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• A Study of NTRX-07 in Participants With Alzheimer's Disease
  NCT07058688 · Phase: Phase 2 · Ages: 65 Years to 80 Years · Sex: All (male and female) · 6 locations
• ADRC Clinical Cohort (Alzheimer's Disease)
  NCT06703541 · Phase: Not specified · Ages: 25 Years to 80 Years · Sex: All (male and female) · 1 location
• Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
  NCT05655325 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years and older · Sex: All (male and female) · 2 locations
• Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
  NCT03657745 · Phase: Not specified · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
  NCT05748613 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 6 locations
• Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
  NCT06733714 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Auditory Sleep Stimulation or Sham in People With Parkinson Disease Mild Cognitive Impairment During Cognitive Training
  NCT07441915 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Autoimmune Features of Neurodegenerative Disorders
  NCT04239079 · Phase: Not specified · Ages: 55 Years to 90 Years · Sex: All (male and female) · 2 locations
• Binaural Beats for Cognitive Function in Older Adults With Mild Cognitive Impairment in Nursing Homes
  NCT07735910 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 3 locations
• Blood Tests for Alzheimer's Disease: Can Plasma Biomarkers Diagnose and Predict Disease Progression
  NCT07717567 · Phase: Not specified · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• CBD for Individuals at Risk for Alzheimer's Disease
  NCT05822362 · Phase: Phase 2 · Ages: 55 Years to 85 Years · Sex: All (male and female) · 1 location
• COMMETS- Combination MCI Metabolic Syndrome
  NCT06072963 · Phase: Phase 2 · Ages: 60 Years to 90 Years · Sex: All (male and female) · 1 location
• Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
  NCT07154394 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)
  NCT06650969 · Phase: Not specified · Ages: 45 Years and older · Sex: All (male and female) · 1 location
• China Longitudinal Aging and Cognitive Impairment Study
  NCT05468905 · Phase: Not specified · Ages: 40 Years to 99 Years · Sex: All (male and female) · 2 locations
• Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
  NCT05907343 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 90 Years · Sex: All (male and female) · 1 location
• Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
  NCT05795634 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
  NCT05968703 · Phase: Not applicable (e.g. observational or device study) · Ages: 21 Years to 80 Years · Sex: All (male and female) · 1 location
• Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
  NCT04124029 · Phase: Not specified · Ages: 30 Years to 90 Years · Sex: All (male and female) · 1 location
• DC Longitudinal Study on Aging and Specimen Bank
  NCT03702907 · Phase: Not specified · Ages: 45 Years and older · Sex: All (male and female) · 1 location
• Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
  NCT03665831 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 2 locations
• Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
  NCT06584357 · Phase: Not specified · Ages: 60 Years to 90 Years · Sex: All (male and female) · 26 locations
• Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
  NCT05881239 · Phase: Not specified · Ages: 18 Years to 100 Years · Sex: All (male and female) · 1 location
• Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
  NCT03954899 · Phase: Not applicable (e.g. observational or device study) · Ages: 56 Years to 85 Years · Sex: All (male and female) · 1 location
• ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
  NCT04335994 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 1 location
• EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment
  NCT05790707 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 80 Years · Sex: All (male and female) · 8 locations
• Effectiveness of TeleVR App in Cognitive Decline and MCI Patients
  NCT06793735 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
  NCT06561906 · Phase: Not specified · Ages: 50 Years to 79 Years · Sex: All (male and female) · 1 location
• Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
  NCT05929703 · Phase: Not applicable (e.g. observational or device study) · Ages: 70 Years and older · Sex: All (male and female) · 7 locations
• Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment
  NCT07416799 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years to 80 Years · Sex: All (male and female) · 1 location
• Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study
  NCT03020381 · Phase: Not specified · Ages: 60 Years to 85 Years · Sex: All (male and female) · 1 location
• HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
  NCT06993207 · Phase: Not specified · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Human Mesenchymal Stem Cells & Monoclonal Antibodies in the Treatment for Mild Cognitive Impairment or Early Alzheimer's Disease.
  NCT07512362 · Phase: Phase 2 · Ages: 55 Years to 90 Years · Sex: All (male and female) · 1 location
• Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
  NCT06897670 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive Impairment
  NCT07334392 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
  NCT06529744 · Phase: Not specified · Ages: 30 Years to 95 Years · Sex: All (male and female) · 8 locations
• Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
  NCT05904132 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 80 Years · Sex: All (male and female) · 1 location
• Innate Immunity Stimulation Via TLR9 in Early AD
  NCT05606341 · Phase: Phase 1 · Ages: 60 Years to 85 Years · Sex: All (male and female) · 1 location
• Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ)
  NCT06889818 · Phase: Not specified · Ages: 19 Years and older · Sex: All (male and female) · 3 locations
• Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
  NCT06484244 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 90 Years · Sex: All (male and female) · 1 location
• Longitudinal Cognitive Assessment by BoCA
  NCT04114994 · Phase: Not specified · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
  NCT03851523 · Phase: Not specified · Ages: 45 Years and older · Sex: All (male and female) · 1 location
• Mazdutide in Type 2 Diabetes With Early-Stage Cognitive Impairment (LIGHT-COG Study)
  NCT07083154 · Phase: Phase 3 · Ages: 50 Years to 75 Years · Sex: All (male and female) · 8 locations
• Microbiome in Aging of Gut and Brain
  NCT07799402 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Multimodal Assesment of Alzheimer Patients
  NCT06448403 · Phase: Not specified · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Music Therapy for Patients With Alzheimer's Disease
  NCT05151562 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 89 Years · Sex: All (male and female) · 1 location
• Music for Pain and Dementia
  NCT07602283 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 80 Years · Sex: All (male and female) · 2 locations
• Natives Engaged in Alzheimers Research - 'Ike Kupuna
  NCT05534607 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 75 Years · Sex: All (male and female) · 3 locations
• Neuclare Device for Temporary Improvement of Executive Function in Patients With Mild Cognitive Impairment and Prodromal Alzheimer's Disease
  NCT07239310 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years to 90 Years · Sex: All (male and female) · 7 locations
• NeuroCare Community Project: A Community Based Prospective Observational Study for Early Alzheimer's Detection in HK
  NCT07347574 · Phase: Not specified · Ages: 60 Years to 75 Years · Sex: All (male and female) · 1 location
• Novel Augmentation of DAOIB and Antioxidant for Early Dementia
  NCT06467539 · Phase: Phase 2 · Ages: 50 Years to 90 Years · Sex: All (male and female) · 1 location
• OCT Angiography and NRAI in Dementia
  NCT03761381 · Phase: Not specified · Ages: 55 Years and older · Sex: All (male and female) · 1 location
• OTC Hearing Aid and MCI
  NCT06112860 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 90 Years · Sex: All (male and female) · 3 locations
• Optical Neuroimaging and Cognition
  NCT05460143 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
  NCT04396873 · Phase: Phase 1 · Ages: 18 Years to 99 Years · Sex: All (male and female) · 2 locations
• PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
  NCT07169630 · Phase: Phase 1 · Ages: 50 Years to 100 Years · Sex: All (male and female) · 1 location
• Paper-Based and Smartphone-Based Memory Supports
  NCT06444841 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 3 locations
• Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
  NCT05245903 · Phase: Not specified · Ages: 18 Years to 89 Years · Sex: All (male and female) · 1 location
• Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients
  NCT05016219 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years and older · Sex: All (male and female) · 2 locations
• Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
  NCT04123314 · Phase: Early Phase 1 · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD
  NCT04500847 · Phase: Phase 1 · Ages: 50 Years to 85 Years · Sex: All (male and female) · 2 locations
• Retinal Imaging in Neurodegenerative Disease
  NCT03233646 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
  NCT05591027 · Phase: Phase 1 · Ages: 60 Years to 85 Years · Sex: All (male and female) · 1 location
• Screening for Anti-amyloid Treatment Eligibility Using Digital Cognition and Blood-based Biomarkers
  NCT07041450 · Phase: Not specified · Ages: 55 Years to 90 Years · Sex: All (male and female) · 1 location
• Senicapoc in Alzheimer's Disease
  NCT04804241 · Phase: Phase 2 · Ages: 55 Years to 85 Years · Sex: All (male and female) · 2 locations
• Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease
  NCT05887674 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 90 Years · Sex: All (male and female) · 1 location
• Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
  NCT05565833 · Phase: Phase 2 · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Spatial Navigation for the Early Detection of Alzheimer's Disease.
  NCT06385951 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 80 Years · Sex: All (male and female) · 1 location
• Study to Understand Novel Biomarkers in Researching Dementia
  NCT06547099 · Phase: Not specified · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Superior Parietal iTBS for PD-MCI
  NCT07701785 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 85 Years · Sex: All (male and female) · 1 location
• TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
  NCT06548191 · Phase: Phase 1 · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Tennessee Alzheimer's Project
  NCT05372172 · Phase: Not specified · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• The Early Warning System for the Diabetic Encephalopathy
  NCT02420470 · Phase: Not specified · Ages: 40 Years to 65 Years · Sex: All (male and female) · 1 location
• The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
  NCT06335836 · Phase: Not specified · Ages: 45 Years to 85 Years · Sex: All (male and female) · 1 location
• The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairment
  NCT07395960 · Phase: Phase 1, Phase 2 · Ages: 60 Years to 75 Years · Sex: All (male and female) · 1 location
• The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
  NCT07786116 · Phase: Not applicable (e.g. observational or device study) · Ages: 55 Years and older · Sex: All (male and female) · 2 locations
• The Swedish BioFINDER - Memory Clinic Study
  NCT06122415 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• The Swedish BioFINDER - Preclinical AD Study
  NCT06121544 · Phase: Not specified · Ages: 50 Years to 80 Years · Sex: All (male and female) · 1 location
• The Swedish BioFINDER - Primary Care Study
  NCT06120361 · Phase: Not specified · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• The Swedish BioFINDER 2 Study
  NCT03174938 · Phase: Not applicable (e.g. observational or device study) · Ages: 20 Years to 100 Years · Sex: All (male and female) · 2 locations
• Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
  NCT06538311 · Phase: Early Phase 1 · Ages: 40 Years to 99 Years · Sex: All (male and female) · 1 location
• Transcranial Magnetic Stimulation for MCI
  NCT05992831 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 85 Years · Sex: All (male and female) · 1 location
• Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
  NCT04601038 · Phase: Phase 2 · Ages: 55 Years and older · Sex: All (male and female) · 1 location
• Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol
  NCT07012993 · Phase: Phase 2 · Ages: 18 Years to 120 Years · Sex: All (male and female) · 1 location
• Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
  NCT04643327 · Phase: Phase 2 · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Understanding Brain Mechanisms Involved in Autobiographical Memory
  NCT05710549 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Uppsala-Dalarna Dementia and Gait Project
  NCT05893524 · Phase: Not specified · Ages: 37 Years to 94 Years · Sex: All (male and female) · 2 locations
• VR Pupillometry in Cognitive Impairment
  NCT07402356 · Phase: Not specified · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Wake Forest Alzheimer's Disease Clinical Core
  NCT03140865 · Phase: Not specified · Ages: 55 Years and older · Sex: All (male and female) · 1 location
• White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
  NCT06179680 · Phase: Not specified · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
  NCT06307574 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 2 locations
• rTMS for Apathy Clinical Trial
  NCT05561205 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 1 location
• rTMS to Improve Cognition in Parkinson's
  NCT03836950 · Phase: Phase 1, Phase 2 · Ages: 50 Years and older · Sex: All (male and female) · 2 locations
• tDCS on Parkinson's Disease Cognition
  NCT03025334 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Mild cognitive impairment often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Mild cognitive impairment trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.