Phase 4 Depression trials recruiting now

All Depression trials, every phase

Other phases for Depression

Phase 4 Depression trials

• A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy
  NCT07456111 · Phase: Phase 4 · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
  NCT07105111 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 22 locations
• A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
  NCT06223880 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 40 locations
• Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
  NCT04245436 · Phase: Phase 4 · Ages: 12 Years to 17 Years · Sex: All (male and female) · 2 locations
• Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression
  NCT07080723 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
  NCT06704594 · Phase: Phase 4 · Ages: 18 Years to 50 Years · Sex: Female · 2 locations
• Aβ Dynamics in LLMD
  NCT05004987 · Phase: Phase 4 · Ages: 60 Years and older · Sex: All (male and female) · 4 locations
• Buspirone and Melatonin for Depression Following Traumatic Brain Injury
  NCT04400266 · Phase: Phase 4 · Ages: 18 Years to 64 Years · Sex: All (male and female) · 2 locations
• Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression
  NCT06278779 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 7 locations
• Comparing Acupuncture With Medication to Reduce Depression, Anxiety and Comorbid Sleep Disorders in China
  NCT07552246 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECT
  NCT05655754 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
  NCT06777758 · Phase: Phase 4 · Ages: 20 Years to 80 Years · Sex: All (male and female) · 1 location
• Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity
  NCT07136714 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Dopaminergic Therapy for Anhedonia - 2
  NCT06075771 · Phase: Phase 4 · Ages: 25 Years to 55 Years · Sex: All (male and female) · 1 location
• ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression
  NCT03272698 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
  NCT07187492 · Phase: Phase 4 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
  NCT07182890 · Phase: Phase 4 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 2 locations
• Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients
  NCT06707012 · Phase: Phase 4 · Ages: 18 Years to 45 Years · Sex: All (male and female) · 4 locations
• Esketamine With or Without Integration Therapy for Treatment-Resistant Depression
  NCT07369102 · Phase: Phase 4 · Ages: 21 Years to 65 Years · Sex: All (male and female) · 2 locations
• Establishing Mobile Transcranial Magnetic Stimulation
  NCT06748209 · Phase: Phase 4 · Ages: 22 Years to 80 Years · Sex: All (male and female) · 2 locations
• Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
  NCT05892744 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Examining the Effects of Estradiol on Neural and Molecular Response to Reward
  NCT05282277 · Phase: Phase 4 · Ages: 45 Years to 55 Years · Sex: Female · 2 locations
• Identifying and Treating Depression in the Orthopaedic Trauma Population
  NCT05976347 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
  NCT06903819 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9)
  NCT05913947 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
  NCT05450432 · Phase: Phase 4 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Metabolic and Behavioural Effects of CONTRAVE as Potential Mechanisms of Weight Loss in Adults With Obesity
  NCT06809166 · Phase: Phase 4 · Ages: 18 Years to 64 Years · Sex: All (male and female) · 9 locations
• Neural Circuit Effects of Ketamine in Depression
  NCT06213324 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Non-invasive BCI and Application Verification for Depressed People
  NCT06417437 · Phase: Phase 4 · Ages: 12 Years and older · Sex: All (male and female) · 1 location
• Optimal Electrical Stimulus During Electroconvulsive Therapy
  NCT04057378 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
  NCT05017311 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 10 locations
• Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
  NCT06610305 · Phase: Phase 4 · Ages: 18 Years to 45 Years · Sex: Female · 1 location
• PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.
  NCT07095205 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Personalized Indications for CBT and Antidepressants in Treating Depression
  NCT02752542 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Positioning of Esketamine Treatment in the Real-world Management of Depression
  NCT06103760 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
  NCT06004115 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
  NCT07266545 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Reward-specific Changes of the Chemical Messenger Dopamine in the Brain of Healthy and Depressed People
  NCT06675851 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulation (iTBS) in Patients With Depression
  NCT07026461 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
  NCT05851898 · Phase: Phase 4 · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children
  NCT07478796 · Phase: Phase 4 · Ages: 12 Years and older · Sex: All (male and female) · 1 location
• The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
  NCT07699445 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• The Role of mGluR5 in CBT-I
  NCT07076342 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Trazodone on NREM Sleep Stage Ⅲ in Depressed Insomniac Co-morbid Patients
  NCT06740188 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum Depression
  NCT06833788 · Phase: Phase 4 · Ages: 18 Years and older · Sex: Female · 1 location
• Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant
  NCT07432815 · Phase: Phase 4 · Ages: 18 Years to 60 Years · Sex: All (male and female) · 3 locations

Common questions

What does Phase 4 mean?

See how clinical trials work.

Is this list complete?

No. For the full record, search ClinicalTrials.gov.