Clinical trials recruiting for Major depressive disorder

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• 40 Hz Light Neurostimulation for Patients With Depression (FELIX)
  NCT05680220 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• 5-HTP and Creatine for Depression R33 Phase
  NCT05895747 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
  NCT06820723 · Phase: Phase 2 · Ages: 21 Years to 65 Years · Sex: All (male and female) · 1 location
• A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
  NCT07115329 · Phase: Phase 2 · Ages: 18 Years to 64 Years · Sex: All (male and female) · 32 locations
• A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD
  NCT06236880 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
  NCT07592689 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · 30 locations
• A Randomized Neuroimaging Trial of Psilocybin in Depression
  NCT06072898 · Phase: Phase 2 · Ages: 18 Years to 64 Years · Sex: All (male and female) · 1 location
• A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
  NCT06775379 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · 51 locations
• A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
  NCT07076407 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · 50 locations
• A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
  NCT07276997 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 33 locations
• A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
  NCT07105111 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 22 locations
• A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
  NCT06223880 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 40 locations
• A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
  NCT07196501 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 60 locations
• Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
  NCT06523439 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 20 Years · Sex: All (male and female) · 1 location
• Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
  NCT05913960 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 45 Years · Sex: All (male and female) · 1 location
• Accelerated TMS for Perinatal Depression
  NCT06968390 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: Female · 1 location
• Accelerated Treatment of Depressive Patients With tDCS
  NCT07444242 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive Disorder
  NCT07768397 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Adolescent Interpersonal Counseling in Primary Care
  NCT06390462 · Phase: Not specified · Ages: 13 Years to 16 Years · Sex: All (male and female) · 4 locations
• Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
  NCT05703256 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• An Empirical Study on the Mechanisms of Biopsychosocial Functional Improvement in Patients With Major Depressive Disorder Through Nature-Based Tourism Activities
  NCT07180342 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 59 Years · Sex: All (male and female) · 2 locations
• An Individual-specific Synchrony Signature
  NCT06749392 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Antidepressant Response of DMT Masked With Propofol
  NCT06927076 · Phase: Not applicable (e.g. observational or device study) · Ages: 21 Years and older · Sex: All (male and female) · 1 location
• Aβ Dynamics in LLMD
  NCT05004987 · Phase: Phase 4 · Ages: 60 Years and older · Sex: All (male and female) · 4 locations
• Basal Plasma Lithium Levels and Suicidal Events
  NCT05409794 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
  NCT05630963 · Phase: Not specified · Ages: 18 Years to 45 Years · Sex: All (male and female) · 1 location
• Biomarker-guided rTMS for Treatment Resistant Depression
  NCT04041479 · Phase: Phase 3 · Ages: 22 Years to 65 Years · Sex: All (male and female) · 2 locations
• Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
  NCT05925322 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 80 Years · Sex: All (male and female) · 1 location
• CARED : A Novel Rapid Treatment Paradigm for Depression
  NCT07507370 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
  NCT06132581 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders
  NCT06450704 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 5 locations
• Chinese Longitudinal and Systematic Study of Bioplar Disorder
  NCT05480150 · Phase: Not applicable (e.g. observational or device study) · Ages: 16 Years to 65 Years · Sex: All (male and female) · 1 location
• Cohort Study on Medical Students' Mental Health
  NCT07305701 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Comorbid Obesity and Depression With an Anti-inflammatory Medication
  NCT06537921 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• DBS for Depression
  NCT03437928 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 70 Years · Sex: All (male and female) · 2 locations
• DBS for TRD With the Medtronic Percept PC
  NCT05773755 · Phase: Not applicable (e.g. observational or device study) · Ages: 25 Years to 70 Years · Sex: All (male and female) · 1 location
• Decoding and Modulating Affective Brain States
  NCT05437705 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
  NCT03665831 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 2 locations
• Defining Neurobiological Links Between Substance Use and Mental Illness
  NCT05538910 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity
  NCT07136714 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• E-field Guided iTBS for Treatment Resistant Depression
  NCT05583747 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder
  NCT07703722 · Phase: Phase 3 · Ages: 18 Years to 60 Years · Sex: All (male and female) · 3 locations
• Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial
  NCT05142683 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 18 Years · Sex: All (male and female) · 1 location
• Efficacy of Statins Among Major Depressive Disorder
  NCT06698666 · Phase: Phase 3 · Ages: 20 Years to 45 Years · Sex: All (male and female) · 1 location
• Enhancing Veteran-Clinical Collaboration in VA PRRCs
  NCT06898879 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 6 locations
• Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
  NCT05892744 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Evaluating tDCS Brain-stimulation in Depression Using MRI
  NCT05598034 · Phase: Not applicable (e.g. observational or device study) · Ages: 20 Years to 55 Years · Sex: All (male and female) · 1 location
• Evaluation of a Male-specific Psychotherapeutic Program for Major Depressive Disorders
  NCT05435222 · Phase: Not applicable (e.g. observational or device study) · Ages: 25 Years to 50 Years · Sex: Male · 1 location
• Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects
  NCT06507787 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 7 locations
• Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
  NCT05051618 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 64 Years · Sex: All (male and female) · 1 location
• Exercise-priming of CBT for Depression: the CBT+ Trial
  NCT07221929 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression
  NCT04935619 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
  NCT07111390 · Phase: Not applicable (e.g. observational or device study) · Ages: 24 Years to 65 Years · Sex: All (male and female) · 1 location
• Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
  NCT06480201 · Phase: Phase 1 · Ages: 21 Years to 45 Years · Sex: All (male and female) · 2 locations
• Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis Use
  NCT03601026 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 21 Years · Sex: All (male and female) · 1 location
• Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
  NCT05327699 · Phase: Early Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness
  NCT07316803 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder
  NCT05644301 · Phase: Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 3 locations
• Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
  NCT06897670 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation
  NCT06542094 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Imaging Depression in Parkinson's Disease
  NCT06402955 · Phase: Phase 2 · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• Impact of Psychomotor Therapy on the Quality of Life in Depression
  NCT06234176 · Phase: Not applicable (e.g. observational or device study) · Ages: 20 Years to 60 Years · Sex: All (male and female) · 1 location
• In Vivo Cortical Excitability Modulation in Major Depressive Disorder
  NCT05441969 · Phase: Not specified · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• In-patient SCC TMS
  NCT05645575 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Integrated Suicide & Trauma Therapy for Suicide Risk
  NCT05613972 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure
  NCT05603104 · Phase: Phase 3 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Interleaved TMS-fMRI in Ultra-treatment Resistant Depression
  NCT05813093 · Phase: Not applicable (e.g. observational or device study) · Ages: 20 Years to 65 Years · Sex: All (male and female) · 1 location
• Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients
  NCT05239780 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
  NCT05996900 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• JAK Signaling in Depression
  NCT07003997 · Phase: Phase 2 · Ages: 25 Years to 55 Years · Sex: All (male and female) · 1 location
• Ketamine Augmentation of ECT in Treatment-Resistant Depression
  NCT07088380 · Phase: Phase 3 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
  NCT06559826 · Phase: Phase 2 · Ages: 18 Years to 90 Years · Sex: All (male and female) · 1 location
• Left vs. Right Non-Inferiority Trial
  NCT04999553 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
  NCT06860724 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
  NCT05450432 · Phase: Phase 4 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
  NCT06966401 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 106 locations
• Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
  NCT06529029 · Phase: Phase 2, Phase 3 · Ages: 18 Years to 90 Years · Sex: All (male and female) · 1 location
• Magnesium Bisglycinate in Major Depressive Disorder
  NCT07633080 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Maintenance rTMS for Depression (Maitr-De)
  NCT06938841 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 3 locations
• Maternal Mental Health Trial
  NCT04685148 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 45 Years · Sex: Female · 1 location
• Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial
  NCT06626152 · Phase: Phase 2 · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
  NCT03973268 · Phase: Phase 1 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Mechanisms of Rumination Change in Adolescent Depression
  NCT03859297 · Phase: Not applicable (e.g. observational or device study) · Ages: 14 Years to 17 Years · Sex: All (male and female) · 3 locations
• Metabolic Profiling of Esketamine Treatment in Depressive Disorder
  NCT07002684 · Phase: Not specified · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• MicroRNA Correlates of Childhood Maltreatment and Suicidality
  NCT04923685 · Phase: Not specified · Ages: 18 Years to 60 Years · Sex: All (male and female) · 2 locations
• Mindful Self-Compassion for Anxiety Disorders and Depression
  NCT05671419 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method
  NCT07028216 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Mindfulness Engaged Neurostimulation for Depression (MEND II)
  NCT07512284 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy
  NCT07473648 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 80 Years · Sex: All (male and female) · 1 location
• NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
  NCT06911112 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 39 locations
• NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
  NCT06963021 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 35 locations
• NMDA Modulation in Antidepressant Nonresponders With Major Depressive Disorder
  NCT05136755 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• NMDA Modulation in Major Depressive Disorder
  NCT04637620 · Phase: Phase 2 · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Natural History of Depression, Bipolar Disorder and Suicide Risk
  NCT06462196 · Phase: Not specified · Ages: 18 Years to 120 Years · Sex: All (male and female) · 1 location
• Near Infrared Spectroscopy (NIRS) for Assessment of Depression
  NCT04061148 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Neural Circuit Effects of Ketamine in Depression
  NCT06213324 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Neural Correlates of Stress and Perceived Control in Adolescent Depression
  NCT04788524 · Phase: Not applicable (e.g. observational or device study) · Ages: 14 Years to 18 Years · Sex: Female · 1 location
• Neural Response to Inflammatory Challenge in Major Depressive Disorder
  NCT04751331 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
  NCT05437588 · Phase: Not applicable (e.g. observational or device study) · Ages: 10 Years to 24 Years · Sex: All (male and female) · 2 locations
• Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
  NCT05570812 · Phase: Phase 2 · Ages: 18 Years to 85 Years · Sex: All (male and female) · 2 locations

Related conditions

Trials recruiting for Major depressive disorder often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Major depressive disorder trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.