Clinical trials recruiting for Depressive Disorder, Major

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

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Recruiting trials

• A Study of Brenipatide in Adult Participants With Major Depressive Disorder
  NCT07412756 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 179 locations
• A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
  NCT07573176 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · 39 locations
• A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
  NCT07227454 · Phase: Phase 3 · Ages: 12 Years to 17 Years · Sex: All (male and female) · 39 locations
• Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
  NCT05491538 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Aerobic Versus Leisure Group for Adolescents With Depression
  NCT05076214 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 17 Years · Sex: All (male and female) · 4 locations
• Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
  NCT05915013 · Phase: Phase 1 · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Biomarkers of Depression and Treatment Response
  NCT04581902 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Clinical Efficacy, Safety, and Applicability of Home-based Bright Light Therapy in Outpatient Adolescents With Major Depressive Disorder
  NCT06913309 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 17 Years · Sex: All (male and female) · 3 locations
• Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
  NCT06136546 · Phase: Phase 2 · Ages: 25 Years to 50 Years · Sex: All (male and female) · 1 location
• Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
  NCT06528938 · Phase: Not applicable (e.g. observational or device study) · Ages: 16 Years to 19 Years · Sex: All (male and female) · 1 location
• Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression
  NCT06152705 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation
  NCT05909267 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Dosing rTMS for Depression Post-SCI
  NCT05553353 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Effectiveness of an Ecological Momentary Emotion Regulation Intervention
  NCT06311136 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI
  NCT06005194 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 64 Years · Sex: All (male and female) · 1 location
• Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
  NCT06511908 · Phase: Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients
  NCT07540585 · Phase: Not specified · Ages: 18 Years to 100 Years · Sex: Female · 1 location
• NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
  NCT02994433 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Optimal Electrical Stimulus During Electroconvulsive Therapy
  NCT04057378 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Peer-led Intervention for Individuals With Major Depression.
  NCT06398561 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
  NCT05232032 · Phase: Phase 2 · Ages: 18 Years to 45 Years · Sex: All (male and female) · 1 location
• Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
  NCT06559306 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · 205 locations
• Precision Medicine in the Depression Treatment
  NCT05616559 · Phase: Not specified · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Prediction of Antidepressant Effects of Electroconvulsive Therapy
  NCT05630469 · Phase: Not specified · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Psychoeducational Intervention for Families With a Member Affected by Major Depression
  NCT05988333 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients
  NCT06860958 · Phase: Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia
  NCT06982820 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 75 Years · Sex: All (male and female) · 3 locations
• The Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People With Obesity and Major Depressive Disorder
  NCT06621394 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The Effects of Exercise on Gut Bacteria, Mood and Cognition in Depression
  NCT06398496 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 59 Years · Sex: All (male and female) · 1 location
• The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder
  NCT04984512 · Phase: Phase 2, Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• The Motor Activity - Subjective Energy (MASE) Project
  NCT07059234 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS
  NCT04870255 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• bWell-D Pilot Randomized Controlled Trial
  NCT06546917 · Phase: Not applicable (e.g. observational or device study) · Ages: 19 Years to 55 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Depressive Disorder, Major often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Depressive Disorder, Major trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.