Clinical trials recruiting for Depressive Disorder, Treatment-Resistant

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
  NCT07716098 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 15 locations
• ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
  NCT07284667 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 26 locations
• Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
  NCT06854367 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 2 locations
• Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment
  NCT04956016 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Intravenous Ketamine for Treatment-Resistant Depression
  NCT06668571 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
  NCT06511908 · Phase: Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
  NCT02994433 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• OSU6162 as add-on in SSRI/SNRI-resistant Depression
  NCT05641623 · Phase: Phase 2 · Ages: 25 Years to 75 Years · Sex: All (male and female) · 4 locations
• One-Day cTBS Over the Precuneus
  NCT07758010 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• rTMS With and Without Text4Support for the Treatment of Resistant Depression.
  NCT05570344 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations

Related conditions

Trials recruiting for Depressive Disorder, Treatment-Resistant often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Depressive Disorder, Treatment-Resistant trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.