Clinical trials recruiting for Treatment-resistant Depression (TRD)

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• ALTO-207 in Adults With Treatment-resistant Depression (TRD)
  NCT07553637 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 48 locations
• Accelerated iTBS for Major Depression
  NCT07603804 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression
  NCT07080723 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Cannabidiol Oil for Treatment-Resistant Major Depression
  NCT07696871 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 69 Years · Sex: All (male and female) · 1 location
• Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
  NCT07563868 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression
  NCT07324070 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
  NCT07146503 · Phase: Not specified · Ages: 18 Years to 74 Years · Sex: All (male and female) · 10 locations
• Esketamine With or Without Integration Therapy for Treatment-Resistant Depression
  NCT07369102 · Phase: Phase 4 · Ages: 21 Years to 65 Years · Sex: All (male and female) · 2 locations
• Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression
  NCT06773949 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
  NCT07094789 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Intravenous Ketamine for Treatment-Resistant Depression
  NCT06668571 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Lumateperone for Late-Life Depression
  NCT07623135 · Phase: Phase 3 · Ages: 60 Years and older · Sex: All (male and female) · 2 locations
• Personalized DBS Targeting for Treating Depression
  NCT06784388 · Phase: Early Phase 1 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
  NCT07217223 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• TACS on High-inflammatory and Refractory Depression
  NCT06812923 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression
  NCT07543328 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Treatment Resistant Depression and Vagus Nerve Stimulation
  NCT05952674 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 24 locations

Related conditions

Trials recruiting for Treatment-resistant Depression (TRD) often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Treatment-resistant Depression (TRD) trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.