Clinical trials recruiting for Heart Failure with Preserved Ejection Fraction (HFPEF)

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
  NCT07219511 · Phase: Phase 1 · Ages: 50 Years and older · Sex: All (male and female) · 21 locations
• A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity
  NCT06862908 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
  NCT07761117 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 672 locations
• AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices
  NCT06909682 · Phase: Not specified · Ages: 19 Years and older · Sex: All (male and female) · 1 location
• Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Outcomes With the Prognosis of Heart Failure With Preserved Ejection Fraction
  NCT06803849 · Phase: Not specified · Ages: 60 Years to 74 Years · Sex: Female · 1 location
• Characteristics, Phenotypes, and TRAITS of Heart Failure With Preserved Ejection Fraction (TRAITS-HFpEF)
  NCT05383287 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Copenhagen Heart Failure With Preserved Ejection Fraction
  NCT06685237 · Phase: Not specified · Ages: 50 Years to 89 Years · Sex: All (male and female) · 1 location
• Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction
  NCT07560436 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
  NCT07185100 · Phase: Not specified · Ages: 40 Years to 69 Years · Sex: All (male and female) · 1 location
• ELEVATE-HFpEF Clinical Study
  NCT06678841 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 50 locations
• Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF
  NCT04592445 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 20 locations
• Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition
  NCT04822649 · Phase: Not applicable (e.g. observational or device study) · Ages: 20 Years to 80 Years · Sex: All (male and female) · 1 location
• Feasibility and Effectiveness of Eccentric Exercise in Sarcopenic Older Adults with Heart Failure: a Pilot Study
  NCT06826963 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 85 Years · Sex: All (male and female) · 2 locations
• Hearts on Fire: Targeting Inflammation in Heart Failure With Preserved Ejection Fraction
  NCT07634640 · Phase: Early Phase 1 · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
  NCT07324772 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 99 Years · Sex: All (male and female) · 2 locations
• Platelet Derived Growth Factor Receptor ß (PDGFRß) Imaging in Cardiac Fibrosis
  NCT06956560 · Phase: Not specified · Ages: 40 Years to 70 Years · Sex: All (male and female) · 1 location
• Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
  NCT06560762 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
  NCT07052539 · Phase: Not specified · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
  NCT06768437 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• The Use of Advanced Imaging in HFpEF
  NCT06905405 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication
  NCT07272902 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• UK Heart Failure With Preserved Ejection Fraction
  NCT05441839 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 26 locations
• Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF
  NCT03876223 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations

Related conditions

Trials recruiting for Heart Failure with Preserved Ejection Fraction (HFPEF) often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Heart Failure with Preserved Ejection Fraction (HFPEF) trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.