Clinical trials recruiting for Knee osteoarthritis

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

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Recruiting trials

• "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
  NCT07198750 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• "Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis"
  NCT06971016 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• A Clinical Study to Evaluate the Safety, Tolerability and Efficacy of BBM-A101 in the Treatment of Knee Osteoarthritis.
  NCT07198555 · Phase: Phase 1 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 2 locations
• A Comparative Study on the Safety and Efficacy of the Intra-Articular Injectable Filler ALLOHEAL in Patients With Knee Osteoarthritis
  NCT07513415 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• A Multi-centre Study of Shoe-worn Insoles and Knee Osteoarthritis
  NCT06251167 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial
  NCT07754175 · Phase: Not specified · Ages: 19 Years and older · Sex: All (male and female) · 2 locations
• A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
  NCT06040827 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 7 locations
• A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
  NCT06906939 · Phase: Early Phase 1 · Ages: 50 Years to 95 Years · Sex: All (male and female) · 1 location
• A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
  NCT07734311 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients
  NCT07219771 · Phase: Phase 3 · Ages: 40 Years to 80 Years · Sex: All (male and female) · 17 locations
• ACB With S-ESPB Versus ACB With iPACK for Knee Arthroplasty
  NCT07288970 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 100 Years · Sex: All (male and female) · 1 location
• Adapting Rehabilitation Delivery for Maximum Impact at Home-2 (ReDI-2)
  NCT07055113 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
  NCT06570291 · Phase: Phase 3 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 2 locations
• Allogenic Mesenchymal Stem Cell Intraarticular Injection for Knee Osteoarthritis Therapy
  NCT05933434 · Phase: Phase 1, Phase 2 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• An Artificial Intelligence-based Approach in Total Knee Arthroplasty: From Inflammatory Responses to Personalized Medicine
  NCT06634654 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Analysis of Protein Expression in Serum of KOA Subjects
  NCT06553313 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Anatomical Axis on X-Ray and Its Relationship With Pain and Kinesiophobia in Knee Osteoarthritis
  NCT07168590 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Anti-Gravity Treadmill Gait Training for Knee Osteoarthritis
  NCT07813078 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 70 Years · Sex: All (male and female) · 1 location
• Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction
  NCT07721116 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms
  NCT07472088 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• BioPoly® Partial Resurfacing Knee Implant IDE
  NCT06915363 · Phase: Not applicable (e.g. observational or device study) · Ages: 30 Years to 65 Years · Sex: All (male and female) · 4 locations
• Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis
  NCT06040957 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• Bowen Technique With Retro-walking on Hamstring Flexibility in Knee Osteoarthritis
  NCT07238751 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 60 Years · Sex: All (male and female) · 1 location
• Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
  NCT06245109 · Phase: Phase 4 · Ages: 41 Years and older · Sex: All (male and female) · 1 location
• Clinical Cohort Study of Knee Arthroplasty Assisted by Digital Technology
  NCT06010979 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis
  NCT06357741 · Phase: Not specified · Ages: 45 Years to 75 Years · Sex: All (male and female) · 1 location
• Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement
  NCT06462625 · Phase: Not specified · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Comparative Effects Of Dynamic And Static Stretching In Postmenopausal Females With Knee Osteoarthritis
  NCT06658327 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 65 Years · Sex: Female · 1 location
• Comparative Efficacy of Intra-articular vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management
  NCT06755697 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 80 Years · Sex: All (male and female) · 1 location
• Comparing the Efficacy of Lyophilized Self Growth Factor Versus PRP Injection for Knee OA
  NCT06932614 · Phase: Not applicable (e.g. observational or device study) · Ages: 20 Years to 80 Years · Sex: All (male and female) · 1 location
• Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement in Knee Osteoarthritis
  NCT07484529 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 65 Years · Sex: All (male and female) · 1 location
• Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain
  NCT05407610 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 15 locations
• Comparison of Custom and Standard Total Knee Replacements
  NCT06122727 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 70 Years · Sex: All (male and female) · 1 location
• Comparison of Functional Recovery After Total Knee Arthroplasty Between Low Phase Angle and High Phase Angle Group
  NCT06701474 · Phase: Not specified · Ages: 55 Years and older · Sex: All (male and female) · 1 location
• Comparison of Image Based Robotic Total Knee Arthroplasty vs Imageless Augmented Reality Assisted Total Knee Arthroplasty
  NCT06891807 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
  NCT06781463 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Crosscultural Adaptation And Validation Of The Italian Version Of The New Knee Society Knee Scoring System
  NCT06726629 · Phase: Not specified · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis
  NCT07664371 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
  NCT07212699 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA
  NCT07386600 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 100 Years · Sex: All (male and female) · 1 location
• Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain
  NCT05785884 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• Dose-Response Effect of Intra-Articular Ozone in Knee Osteoarthritis
  NCT07678996 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• Effect of Genicular Arteries Embolization in Symptomatic Knee Osteoarthritis LipioJoint-2
  NCT06497140 · Phase: Phase 3 · Ages: 40 Years to 90 Years · Sex: All (male and female) · 3 locations
• Effect of Physical Therapy Rehabilitation on Gait and Plantar Pressure in Patients After Total Knee Replacement
  NCT07556003 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 70 Years · Sex: Female · 1 location
• Effect of Remimazolam and Propofol on Postoperative Delirium
  NCT05514405 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 100 Years · Sex: All (male and female) · 1 location
• Effect of an Information- and Self-management App for People With Knee Osteoarthritis
  NCT07603973 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty
  NCT07248072 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
  NCT06423716 · Phase: Phase 4 · Ages: 50 Years and older · Sex: All (male and female) · 2 locations
• Effectiveness and Safety of Intra-Articular Hyaluronic Acid Conjugated With Fibrinogen in Knee Osteoarthritis
  NCT07323342 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 75 Years · Sex: All (male and female) · 1 location
• Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)
  NCT05823727 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 75 Years · Sex: All (male and female) · 1 location
• Effects of Gait Retraining on Lower Extremity Biomechanics
  NCT03663790 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Effects of Voodoo Flossing Technique in Knee Osteoarthritis Patients
  NCT06986694 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 65 Years · Sex: All (male and female) · 1 location
• Effects of a Yoga Program on the Functionality of Individuals
  NCT07006883 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• Efficacy and Safety of Celecoxib/Acetaminophen Versus Celecoxib for Diagnosed Osteoarthritis in Acute Exacerbation
  NCT06863636 · Phase: Phase 3 · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• Efficacy and Safety of IxCell hUC-MSC-O in Patients With Knee Osteoarthritis
  NCT06716281 · Phase: Phase 3 · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee Osteoarthritis
  NCT05039463 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Efficacy of Artificial Intelligence-Assisted Therapeutic Exercise in Patients With Knee Osteoarthritis
  NCT07434011 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years and older · Sex: All (male and female) · 1 location
• Efficacy of Platelet-Rich Plasma Added to Hyaluronic Acid in Knee Osteoarthritis
  NCT07785401 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Efficacy of Platelet-Rich Plasma Combined With Hyaluronic Acid in Knee Osteoarthritis
  NCT07784907 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis
  NCT07016672 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
  NCT05839535 · Phase: Phase 2 · Ages: 45 Years to 75 Years · Sex: All (male and female) · 1 location
• Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis
  NCT06940479 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Evaluating XPERIENCE™ Advanced Surgical Irrigation
  NCT05543941 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 8 locations
• Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
  NCT06407427 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Evaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement
  NCT05488093 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• Evaluation of a New Bi-Condylar Total Knee Prosthesis (TKP) With All-Ceramic Friction (The Forgotten Knee)
  NCT06592248 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Evaluation of the Effect of SURGICEL® Powder in TKA
  NCT06608992 · Phase: Phase 4 · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Evaluation of the Structural Modification Effect of Diacerein (Artrodar®) in Knee Osteoarthritic Patients
  NCT04318041 · Phase: Phase 3 · Ages: 40 Years to 65 Years · Sex: All (male and female) · 1 location
• Extracorporeal Shockwave Versus Phonophoresis Using Chitosan-Nanoparticles Gel on Functional and Anatomical Changes Detected With Artificial Intelligence Based Texture Analysis Algorithm in Knee Osteoarthritis Patients: A Double Blind Randomized Controlled Trial
  NCT06567301 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 60 Years · Sex: All (male and female) · 2 locations
• FAldini Sport Total Joint Arthroplasty-Knee II
  NCT06383936 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 65 Years · Sex: All (male and female) · 1 location
• FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis
  NCT07625150 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• FitJoints: Getting Fit for Hip and Knee Replacement
  NCT05100966 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 4 locations
• Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial
  NCT04472702 · Phase: Not applicable (e.g. observational or device study) · Ages: 35 Years to 99 Years · Sex: All (male and female) · 2 locations
• Focused Extracorporeal Shockwave Therapy for Knee Arthritis
  NCT05596591 · Phase: Not applicable (e.g. observational or device study) · Ages: 30 Years to 80 Years · Sex: All (male and female) · 2 locations
• Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
  NCT04275362 · Phase: Not specified · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Gait Rehabilitation to Treat FastOA
  NCT05848622 · Phase: Not applicable (e.g. observational or device study) · Ages: 16 Years to 35 Years · Sex: All (male and female) · 1 location
• Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis
  NCT07507175 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 55 Years · Sex: Female · 1 location
• General vs Spinal in Total Joint Arthroplasty (TJA)
  NCT06747494 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Genicular Artery Embolisation for Knee Osteoarthritis II
  NCT05423587 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years and older · Sex: All (male and female) · 1 location
• Genicular Artery Embolization for Knee Osteoarthritis
  NCT07537153 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
  NCT06859164 · Phase: Phase 2 · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• Genicular Artery Embolization vs Nerve Ablation Intervention (GENI) for Knee Osteoarthritis
  NCT06166628 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• HILT Dose Optimization for Knee Osteoarthritis Pain
  NCT06916676 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Hip Abductor Strengthening Exercises in Knee Osteoarthritis
  NCT06845657 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 60 Years · Sex: All (male and female) · 1 location
• Homologous PRP vs Placebo in Knee Osteoarthritis in Over 65 Years Old Patients
  NCT04901273 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Homologus PRP in the Infiltrative Treatment of Knee Osteoarthritis in Young Athletic Patients
  NCT06483269 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 40 Years · Sex: All (male and female) · 1 location
• Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis
  NCT04998188 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITIS
  NCT06600958 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Implementing a Group Physical Therapy Program for Veterans (GroupPT): Function QUERI 3.0
  NCT07215572 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
  NCT06298721 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Innovations in Genicular Outcomes Registry
  NCT05495334 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 19 locations
• Integrated Trunk Stabilization With Osteoarthritis Rehabilitation in Knee-Spine Syndrome
  NCT07484594 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 60 Years · Sex: All (male and female) · 2 locations
• Intra-articular Corticosteroid Injection in GAE for Knee Knee Osteoarthritis
  NCT06514716 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
  NCT03491761 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis
  NCT07666347 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Investigating Patient Satisfaction With Smart Knee Implants
  NCT06968143 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Investigation of the Effect of Proximal and Distal Adductor Canal Block in Knee Replacement Surgery
  NCT06188806 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 85 Years · Sex: All (male and female) · 1 location
• Ischemic Preconditioning in Osteoarthritis and Back Pain
  NCT07003113 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Knee Biofeedback Rehabilitation Through Game Therapy
  NCT06090097 · Phase: Not applicable (e.g. observational or device study) · Ages: 30 Years to 75 Years · Sex: All (male and female) · 1 location
• Knee Ligament Stiffness Across Ethnicities Before and After Osteoarthritis Treatment
  NCT07744789 · Phase: Not specified · Ages: 20 Years and older · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Knee osteoarthritis often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Knee osteoarthritis trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.