Clinical trials recruiting for Treatment-resistant depression

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

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Recruiting trials

• 40 Hz Light Neurostimulation for Patients With Depression (FELIX)
  NCT05680220 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
  NCT04996433 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 8 locations
• A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
  NCT03887715 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 101 locations
• A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
  NCT03320304 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 18 locations
• A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
  NCT06524830 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 48 locations
• An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression
  NCT05660642 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 3 locations
• Belief Updating in Treatment Resistant Depression
  NCT05577247 · Phase: Not specified · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Biomarker-guided rTMS for Treatment Resistant Depression
  NCT04041479 · Phase: Phase 3 · Ages: 22 Years to 65 Years · Sex: All (male and female) · 2 locations
• COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression
  NCT06895863 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 95 Years · Sex: All (male and female) · 3 locations
• Characterizing Synaptic Density in Treatment Resistant Depression
  NCT03537794 · Phase: Not specified · Ages: 25 Years to 65 Years · Sex: All (male and female) · 1 location
• Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression
  NCT06278779 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 7 locations
• Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI
  NCT05377177 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• DBS for Depression
  NCT06096207 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• DBS for TRD With the Medtronic Percept PC
  NCT05773755 · Phase: Not applicable (e.g. observational or device study) · Ages: 25 Years to 70 Years · Sex: All (male and female) · 1 location
• Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
  NCT05905705 · Phase: Not specified · Ages: 21 Years to 65 Years · Sex: All (male and female) · 1 location
• Dutch-Depression Outcome Trial Comparing 5 Day Multi Daily Neuronavigated Theta Burst Sessions With 6 Weeks rTMS
  NCT05900271 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 99 Years · Sex: All (male and female) · 4 locations
• ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression
  NCT03272698 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression
  NCT07211438 · Phase: Phase 2 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 2 locations
• Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
  NCT07094789 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
  NCT06480201 · Phase: Phase 1 · Ages: 21 Years to 45 Years · Sex: All (male and female) · 2 locations
• IV Ketamine vs. IN Esketamine for MDD TRD
  NCT06488586 · Phase: Not specified · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation
  NCT06542094 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
  NCT06512220 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression
  NCT06781697 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Ketamine Augmentation of ECT in Treatment-Resistant Depression
  NCT07088380 · Phase: Phase 3 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
  NCT07108257 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Maintenance rTMS for Depression (Maitr-De)
  NCT06938841 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 3 locations
• Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
  NCT05418894 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 70 Years · Sex: All (male and female) · 1 location
• Mindfulness Engaged Neurostimulation for Depression (MEND II)
  NCT07512284 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Natural History of Depression, Bipolar Disorder and Suicide Risk
  NCT06462196 · Phase: Not specified · Ages: 18 Years to 120 Years · Sex: All (male and female) · 1 location
• Olfactory and Brain Stimulations in Treatment-resistant Depression
  NCT05661383 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• PCS in Severe Treatment Resistant Depression
  NCT04124341 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 70 Years · Sex: All (male and female) · 1 location
• Physical Activity Program for TRD
  NCT06404320 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression
  NCT07183748 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Psilocybin for Hospitalized Patients with Treatment-resistant Depression
  NCT06378229 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Psilocybin rTMS for Treatment Resistant Depression
  NCT06132178 · Phase: Phase 2 · Ages: 22 Years to 65 Years · Sex: All (male and female) · 1 location
• Schema Therapy for Patients With Chronic Treatment Resistant Depression
  NCT05833087 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 6 locations
• The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
  NCT05973851 · Phase: Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 12 locations
• The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression
  NCT06163625 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
  NCT05607654 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 45 Years · Sex: All (male and female) · 1 location
• Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
  NCT03952962 · Phase: Not applicable (e.g. observational or device study) · Ages: 21 Years to 70 Years · Sex: All (male and female) · 1 location
• Transcranial Ultrasonic Stimulation in Treatment-resistant Depression : an Open-label Pilot Trial
  NCT06085950 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Translational Biomarkers in Accelerated Neuromodulation for Treatment-resistant Depression
  NCT05798143 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
  NCT06423430 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 70 Years · Sex: All (male and female) · 25 locations
• Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
  NCT06518720 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression
  NCT07166289 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• University of Iowa Interventional Psychiatry Service Patient Registry
  NCT04480918 · Phase: Not specified · Ages: 18 Years to 99 Years · Sex: All (male and female) · 2 locations
• Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients
  NCT07706478 · Phase: Not specified · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
  NCT06480500 · Phase: Phase 2 · Ages: 21 Years to 65 Years · Sex: All (male and female) · 1 location
• ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder
  NCT07474974 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Treatment-resistant depression often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Treatment-resistant depression trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.