Clinical trials recruiting for Bipolar Depression

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
  NCT07172516 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · 44 locations
• Behavioural Activation for Bipolar Depression
  NCT06022913 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Brexpiprazole Treatment for Bipolar I Depression
  NCT04569448 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 3 locations
• Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
  NCT06599099 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 64 Years · Sex: All (male and female) · 4 locations
• EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT
  NCT07740694 · Phase: Not specified · Ages: 55 Years and older · Sex: All (male and female) · 1 location
• Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression
  NCT06088732 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Efficacy and Safety Assessment of Temporal Interference Stimulation to Improve Bipolar Depression
  NCT07021508 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 45 Years · Sex: All (male and female) · 1 location
• Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression
  NCT06524505 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• HD-tDCS for Adolescent Bipolar Depression Targeting S1
  NCT07246044 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 18 Years · Sex: All (male and female) · 1 location
• Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure
  NCT05603104 · Phase: Phase 3 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Ketogenic Intervention for Bipolar Depression
  NCT07121894 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 50 Years · Sex: All (male and female) · 1 location
• Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
  NCT07108257 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
  NCT06372964 · Phase: Phase 3 · Ages: 10 Years to 17 Years · Sex: All (male and female) · 68 locations
• Non-invasive BCI and Application Verification for Depressed People
  NCT06417437 · Phase: Phase 4 · Ages: 12 Years and older · Sex: All (male and female) · 1 location
• OSU6162 in Bipolar Depression (OBID)
  NCT05296356 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• PROgram To Enhance Cardiovascular Risk Trough an Intervention of Nutrition in Bipolar Disorder
  NCT06488573 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
  NCT07266545 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• SYNCED - SYNChronized Eating in Bipolar Depression Study
  NCT06560957 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Safety and Feasibility of DBS for Bipolar Depression
  NCT07745374 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 70 Years · Sex: All (male and female) · 1 location
• The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
  NCT05973786 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 13 locations
• Theta-Burst Stimulation for Bipolar Depression
  NCT06370988 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• University of Iowa Interventional Psychiatry Service Patient Registry
  NCT04480918 · Phase: Not specified · Ages: 18 Years to 99 Years · Sex: All (male and female) · 2 locations

Related conditions

Trials recruiting for Bipolar Depression often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Bipolar Depression trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.