Clinical trials recruiting for Major Depressive Episode

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
  NCT06523439 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 20 Years · Sex: All (male and female) · 1 location
• Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode
  NCT03646058 · Phase: Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 9 locations
• At-Home tDCS as Maintenance Therapy
  NCT07269964 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders
  NCT05866991 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Comparing Uni- and Bi-lateral TBS in Major Depression
  NCT04142996 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
  NCT06732089 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
  NCT07748091 · Phase: Not specified · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT
  NCT07740694 · Phase: Not specified · Ages: 55 Years and older · Sex: All (male and female) · 1 location
• Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients
  NCT06508710 · Phase: Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 4 locations
• Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
  NCT07111390 · Phase: Not applicable (e.g. observational or device study) · Ages: 24 Years to 65 Years · Sex: All (male and female) · 1 location
• Left vs. Right Non-Inferiority Trial
  NCT04999553 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Metabolomics During ElectroConvulsivoTherapy
  NCT05973643 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Patient-oriented Randomized Pragmatic Feasibility Trial with RTMS in Depression and Anxiety
  NCT05028738 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Personalized Ultrasonic Brain Stimulation for Depression (R61)
  NCT06902298 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Presynaptic Imaging in Major Depressive Episodes After COVID-19
  NCT06086366 · Phase: Not specified · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• The Impact of Coach-guided Risk Communication on the Risk of Major Depression
  NCT06619366 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• University of Iowa Interventional Psychiatry Service Patient Registry
  NCT04480918 · Phase: Not specified · Ages: 18 Years to 99 Years · Sex: All (male and female) · 2 locations
• tDCS: Sleep to Mood in Depression (S2M-D)
  NCT07572526 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Major Depressive Episode often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Major Depressive Episode trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.