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64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer
NCT06298916 ·
Phase: Phase 1, Phase 2 ·
Ages: 15 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati
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A Brief Psychological Intervention to Improve Emotional Well-Being During Neoadjuvant Therapy for Pancreatic Cancer
NCT07124611 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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A Clinical Trial to Evaluate EDV Nanocell Therapy With Gemcitabine and Nab-paclitaxel in Pancreatic Cancer
NCT07049055 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Maumee
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A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors
NCT05932862 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
NCT06881992 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Canton
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A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
NCT03394365 ·
Phase: Phase 3 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Ohio: Cleveland, Columbus
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A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations
NCT06906562 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati, Cleveland, Columbus
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A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT04657068 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati, Maumee
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A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
NCT06465069 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
A Study of LY4170156 in Participants With Selected Advanced Solid Tumors
NCT06400472 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
-
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
NCT06943521 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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A Study of NovoTTF-200T(P) in Combination With Gemcitabine and Nab-Paclitaxel for Resectable Pancreatic Adenocarcinoma
NCT05624918 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
NCT05208762 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT04389632 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
NCT05968326 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati
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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
NCT07522073 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland, Columbus
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A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
NCT07409272 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
NCT06051695 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
NCT07094204 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
NCT06760819 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
NCT04858334 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Centerville, Cincinnati, Dayton, Franklin
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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
NCT07562152 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Maumee
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Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
NCT06651580 ·
Phase: Not specified ·
Ages: Up to 17 Years ·
Sex: All (male and female)
· Ohio: Cincinnati, Columbus
-
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen
NCT07087054 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· Ohio: Akron, Barberton, Beavercreek, Belpre
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Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
NCT04239573 ·
Phase: Not specified ·
Ages: 50 Years to 75 Years ·
Sex: All (male and female)
· Ohio: Beavercreek, Boardman, Centerville, Cincinnati
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Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions
NCT03492151 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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DCE-MRI Guided Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer
NCT06173310 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 19 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
-
DESTINY-PANTUMOUR04
NCT07124000 ·
Phase: Not specified ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· Ohio: Canton, Maumee
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Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response
NCT04588025 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 19 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
NCT06263088 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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Early Diagnosis of Pancreatic Cancer Duodenal Fluid-Based Biomarker Exploratory Study
NCT07030348 ·
Phase: Not specified ·
Ages: 19 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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Endoscopic Ultrasound-Guided Chemoablation for the Treatment of Pancreatic Cystic Neoplasms
NCT07529483 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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Evaluation of Endoscopic Ultrasound-Guided Radiofrequency Ablation for the Management of Pancreatic Tumors, ERASE Study
NCT05961982 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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Evaluation of a Mixed Meal Test for Diagnosis and Characterization and Type 3c Diabetes Mellitus Secondary to Pancreatic Cancer and Chronic Pancreatitis (DETECT)
NCT03460769 ·
Phase: Not specified ·
Ages: 30 Years to 84 Years ·
Sex: All (male and female)
· Ohio: Columbus
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Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer
NCT01954992 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Canton
-
Integrated Cancer Repository for Cancer Research
NCT02012699 ·
Phase: Not specified ·
Ages: 19 Years to 110 Years ·
Sex: All (male and female)
· Ohio: Alliance, Canton
-
Is Intraperitoneal Drainage Necessary Following Distal Pancreatectomy?
NCT05720338 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration
NCT06973564 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
NCT06026410 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
NCT06073431 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Beavercreek, Belpre, Boardman, Cincinnati
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Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula
NCT06807437 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati, Columbus, West Chester
-
Lead-212 PSV359 Therapy for Patients With Solid Tumors
NCT06710756 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Ohio: Columbus
-
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06586515 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati, Cleveland
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MyCap Mobile Application for Tracking Time Burden of Treatment for Patients With Pancreatic Cancer
NCT07619391 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati, Cleveland, Toledo
-
Pan-tumor MRD Study
NCT06605404 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Maumee
-
Pancreatic Cancer Early Detection Consortium
NCT04970056 ·
Phase: Not specified ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Ohio: Columbus
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Prehabilitation for EOC, Fallopian Tube, Primary Peritoneal Carcinoma and Pancreatic Cancer w/ NACT
NCT06412510 ·
Phase: Phase 1, Phase 2 ·
Ages: 65 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma
NCT07259317 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati
-
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Ohio: Cincinnati, Columbus, Mayfield Heights
-
Shwachman Diamond Syndrome Registry and Study
NCT06056908 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Ohio: Cincinnati
-
Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy (SBRT) in Participants With Cancer-Related Celiac Pain
NCT07117032 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
NCT04981119 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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Stereotactic Adaptive Radiation Therapy of Borderline Resectable Pancreatic Cancer an Individualized Approach
NCT05764720 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
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Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase
NCT04195347 ·
Phase: Phase 1, Phase 2 ·
Ages: Up to 21 Years ·
Sex: All (male and female)
· Ohio: Cincinnati
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Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
NCT07030257 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland, Maumee
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Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation
NCT04890613 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
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Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
NCT07252232 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Maumee
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Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
NCT07491445 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati, Maumee
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Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
NCT05254171 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
-
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati
-
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
NCT05379985 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati, Maumee
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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06040541 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cincinnati
-
Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy
NCT05477576 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland, Columbus
-
Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.
NCT07165132 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
-
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
NCT04429542 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
NCT06084481 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors
NCT05985655 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
-
Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations
NCT06998940 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Centerville, Cincinnati, Dayton, Franklin
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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
NCT04851119 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Months to 30 Years ·
Sex: All (male and female)
· Ohio: Cincinnati
-
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
NCT06958328 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Canton, Centerville, Cincinnati, Columbus
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Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
NCT05372614 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
-
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
NCT05040360 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Avon, Beachwood, Centerville, Cincinnati
-
The Cancer of the Pancreas Screening-5 CAPS5)Study
NCT02000089 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland
-
Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer
NCT03711890 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Columbus
-
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
NCT03556228 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Ohio: Maumee
-
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
NCT06943755 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland, Columbus
-
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881 ·
Phase: Not specified ·
Ages: 40 Years and older ·
Sex: All (male and female)
· Ohio: Cleveland