Clinical trials recruiting for Major Depression

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• Accelerated High-Dose tDCS for Depression
  NCT07226011 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Added Value of a Neuroendocrine Test Battery in the Response to Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment
  NCT05964192 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
  NCT02434393 · Phase: Not specified · Ages: 65 Years and older · Sex: All (male and female) · 4 locations
• Combining Light Therapy and CPAP in Depression
  NCT06781593 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
  NCT07748091 · Phase: Not specified · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Effect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive Disorder
  NCT07691749 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Inhaled DMT for Major Depressive Disorder
  NCT07562191 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 5 locations
• Interpersonal Psychotherapy for Adolescents and Young Adults
  NCT05575960 · Phase: Not applicable (e.g. observational or device study) · Ages: 15 Years to 18 Years · Sex: All (male and female) · 1 location
• Ketamine Alcohol (in Treatment-Resistant Depression)
  NCT02122562 · Phase: Phase 2 · Ages: 18 Years to 55 Years · Sex: All (male and female) · 1 location
• Leucine in Midlife Depression
  NCT06580145 · Phase: Phase 2 · Ages: 35 Years to 65 Years · Sex: All (male and female) · 1 location
• Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
  NCT03973268 · Phase: Phase 1 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Modular Intervention for Depression Study
  NCT07380451 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 5 locations
• NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
  NCT05669703 · Phase: Not specified · Ages: 8 Years to 70 Years · Sex: All (male and female) · 2 locations
• Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation
  NCT06763081 · Phase: Not specified · Ages: 6 Years to 24 Years · Sex: All (male and female) · 2 locations
• Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
  NCT07226232 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 5 locations
• RCT of At-Home tDCS for Depression in Pregnancy
  NCT05097586 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: Female · 2 locations
• Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression
  NCT07673913 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: All (male and female) · 2 locations
• Skills for Wellness
  NCT01980147 · Phase: Not applicable (e.g. observational or device study) · Ages: 9 Years to 21 Years · Sex: All (male and female) · 2 locations
• Sleep TMS for Depression
  NCT06824415 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location
• Study of Sleep Inertia in Major Depressive Disorder by the Psychomotor Vigilance Task
  NCT06732284 · Phase: Not specified · Ages: 18 Years to 54 Years · Sex: All (male and female) · 1 location
• Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression
  NCT07813169 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 45 Years · Sex: All (male and female) · 1 location
• Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
  NCT07560878 · Phase: Early Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• University of Iowa Interventional Psychiatry Service Patient Registry
  NCT04480918 · Phase: Not specified · Ages: 18 Years to 99 Years · Sex: All (male and female) · 2 locations
• Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
  NCT07031817 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Major Depression often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Major Depression trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.