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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
NCT07351045 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston, Needham
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A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
NCT06143956 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Massachusetts: Needham, New Bedford
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A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
NCT06672549 ·
Phase: Phase 3 ·
Ages: 6 Years to 17 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
NCT07481630 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Waltham
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A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
NCT07654374 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Massachusetts: Methuen
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A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
NCT07282600 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: New Bedford
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A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
NCT07321886 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Quincy
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A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
NCT07392190 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston, Waltham
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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
NCT07153471 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Waltham
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A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
NCT06239116 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
NCT07589608 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Massachusetts: Needham, New Bedford
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A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)
NCT06857942 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Brighton
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A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
NCT06760546 ·
Phase: Phase 3 ·
Ages: 4 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
NCT07162337 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment
NCT07226947 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Building Connections
NCT07091032 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Cerebellar TMS and Satiety in Prader-Willi Syndrome
NCT05938543 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female)
· Massachusetts: Belmont
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Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline
NCT06432790 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 4 Years to 17 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia
NCT04839614 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female
· Massachusetts: Boston
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EVOC - EVs in Obesity and Cardiometabolic Disease
NCT06408961 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
NCT06138821 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity
NCT05933499 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children
NCT05464186 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 9 Years to 12 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
NCT07654361 ·
Phase: Phase 3 ·
Ages: 18 Years to 79 Years ·
Sex: All (male and female)
· Massachusetts: Methuen, Needham
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Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
NCT07353931 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Burlington, Quincy
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Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure
NCT05711758 ·
Phase: Not specified ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
NCT07284901 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
NCT05728697 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433 ·
Phase: Phase 3 ·
Ages: 45 Years to 99 Years ·
Sex: All (male and female)
· Massachusetts: New Bedford
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Exercise, Brain Activity, and Weight Maintenance
NCT06511310 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
NCT06557005 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female
· Massachusetts: Boston
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Family-Based Weight Wellness Treatment Through Food is Medicine and Group Medical Visits in Pediatric and Adult Primary Care
NCT07717658 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Intermittent Fasting for NAFLD in Adults
NCT04899102 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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International Weight Control Registry
NCT04907396 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population
NCT05799222 ·
Phase: Not specified ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
NCT06937086 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Massachusetts: New Bedford
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Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
NCT06937099 ·
Phase: Phase 3 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Massachusetts: New Bedford
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Myo-inositol During Pregnancy to Prevent Gestational Diabetes
NCT06575868 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: Female
· Massachusetts: Boston
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Nutrition+: Effect of a High-Protein Diabetes Formula on Body Composition in Type 2 Diabetes Patients Treated With Incretin Mimetics
NCT07271043 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Oxytocin for Weight Loss in Adolescents
NCT04551482 ·
Phase: Phase 2 ·
Ages: 10 Years to 18 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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PPDTM CorEvitasTM Obesity (OBR) Drug Effectiveness and Safety Registry
NCT07598981 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Waltham
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Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
NCT07095517 ·
Phase: Phase 1 ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Personalized Responses to Dietary Composition Trial 3
NCT04735835 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Needham
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Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food
NCT06988462 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· Massachusetts: Sommerville
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Postnatal Exercise to Activate Baby's Brown Fat
NCT07467694 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 45 Years ·
Sex: Female
· Massachusetts: Boston
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RESET System Pivotal Trial (Rev F)
NCT04101669 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity
NCT07776678 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment
NCT06069622 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Massachusetts: Boston
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Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.
NCT01998750 ·
Phase: Not specified ·
Ages: Up to 80 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV
NCT06554717 ·
Phase: Phase 2 ·
Ages: 50 Years to 80 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
NCT07699445 ·
Phase: Phase 4 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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The Osteoarthritis Prevention Study
NCT05946044 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years and older ·
Sex: Female
· Massachusetts: Boston
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The Physiology of Human Brown Adipose Tissue
NCT04352244 ·
Phase: Not specified ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Trans-nasal Endoscopy for Bariatric Patients
NCT06200961 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· Massachusetts: Boston
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Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
NCT06105164 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Massachusetts: Belmont, Boston